Thursday, February 9, 2012
Monday, March 31, 2008
Source: Electromagnetic Research & Education Foundation Released: Tue 18-Mar-2008, 15:00 ET
When Science Fiction Becomes Science Fact: Electromagnetism and Life
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Science News Keywords
ELECTROMAGNETIC FIELD-FORCER, PARAMAGNETIC OSCILLATORS-DAMPER, PHONON RESONANCE-SIGNAL SERIES, PROTEIN ITERATION-SYSTEM, CONFORMATIONAL ADAPTATION-OUTCOME
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Description
This first time synthesis by a physician/scientist nullifies the 1910 Flexner Report charge of “irregular science” against electromagnetism by explaining the basic principles of electromagnetic control of cell function. Scheduled as a keynote presentation at the prestigious 2008 IEEE sponsored meeting (www.icbbe.org) on bioinformatics to be held in Shanghai, it lays to rest “you don’t know the mechanism” so often leveled against this universal force. Linus Pauling preceded Stephen Hawking in establishing electromagnetism’s control of chemical reactions, biologic response, and life itself but the precise mechanism underlying that control had not been defined until this paper. A new approach in the treatment of illness and trauma awaits its wider understanding.
Newswise —
Stephen Hawking (A Brief History of Time)-“Electromagnetism Controls All Chemical Reactions, All Biological Response. Life Itself”
This report reflects 25 years of nanosecond pulsed electromagnetic field (nPEMF) investigation, and an interdisciplinary synthesis based upon experimental reports since the 1970s. Electromagnetic fields drive a classic resonance system as forcers that are magneto-acoustically transduced (damped) by paramagnetic-diamagnetic elements to create a phonon driven, non-linear information system, which is iteratively processed by beta sub-units to prime protein conformational adaptive response (folding) of alpha sub-units. This low voltage information system sets the stage for the ATP power system to transport ions and substrate through appropriate channels, regulates DNA, and enhances protein enzyme activity in support of homeostasis. Cell function reflects dual energy systems: 1) a low voltage information circuit guided by principles of physics to control cell function, and 2) a power circuit driving chemical outcomes to complete it.
Dipole forces generate phonons when paramagnetic and diamagnetic elements and small molecules, e.g. amino acids, constrained within a protein matrix, oscillate about their bond lengths to become magneto-acoustic transducers in response to natural or artificial EM fields. When damped within physiologic parameters such transductions conduct heat and sound through proteins in a native (elementary) mode at the speed of sound. While sub-threshold in themselves they achieve resonance with similar phonon harmonics from other strategically self-assembled paramagnetic/diamagnetic constructs (PDCs) within the protein to enhance signal intensity several magnitudes (Kruglikov and Dertinger, 1994.) DNA, and other proteins posses a sophisticated capacity to electively combine such harmonics with other “noise”, i.e. stochastic resonance, to enhance their activity in support of cell function.
Dr. Gordon's paper, entitled “Protein Iteration and Cellular Response to Extrinsic Electromagnetic Forces,” is available on the Web site of The 2nd International Conference on Bioinformatics and Biomedical Engineering at http://www.icbbe.org/icbbe2008submission/website/icbbe/keynoteSpeakers.htm
--------------------------------------------------------------------------------
© 2008 Newswise. All Rights Reserved.
When Science Fiction Becomes Science Fact: Electromagnetism and Life
Libraries
Science News Keywords
ELECTROMAGNETIC FIELD-FORCER, PARAMAGNETIC OSCILLATORS-DAMPER, PHONON RESONANCE-SIGNAL SERIES, PROTEIN ITERATION-SYSTEM, CONFORMATIONAL ADAPTATION-OUTCOME
Contact Information
Available for logged-in reporters only
Description
This first time synthesis by a physician/scientist nullifies the 1910 Flexner Report charge of “irregular science” against electromagnetism by explaining the basic principles of electromagnetic control of cell function. Scheduled as a keynote presentation at the prestigious 2008 IEEE sponsored meeting (www.icbbe.org) on bioinformatics to be held in Shanghai, it lays to rest “you don’t know the mechanism” so often leveled against this universal force. Linus Pauling preceded Stephen Hawking in establishing electromagnetism’s control of chemical reactions, biologic response, and life itself but the precise mechanism underlying that control had not been defined until this paper. A new approach in the treatment of illness and trauma awaits its wider understanding.
Newswise —
Stephen Hawking (A Brief History of Time)-“Electromagnetism Controls All Chemical Reactions, All Biological Response. Life Itself”
This report reflects 25 years of nanosecond pulsed electromagnetic field (nPEMF) investigation, and an interdisciplinary synthesis based upon experimental reports since the 1970s. Electromagnetic fields drive a classic resonance system as forcers that are magneto-acoustically transduced (damped) by paramagnetic-diamagnetic elements to create a phonon driven, non-linear information system, which is iteratively processed by beta sub-units to prime protein conformational adaptive response (folding) of alpha sub-units. This low voltage information system sets the stage for the ATP power system to transport ions and substrate through appropriate channels, regulates DNA, and enhances protein enzyme activity in support of homeostasis. Cell function reflects dual energy systems: 1) a low voltage information circuit guided by principles of physics to control cell function, and 2) a power circuit driving chemical outcomes to complete it.
Dipole forces generate phonons when paramagnetic and diamagnetic elements and small molecules, e.g. amino acids, constrained within a protein matrix, oscillate about their bond lengths to become magneto-acoustic transducers in response to natural or artificial EM fields. When damped within physiologic parameters such transductions conduct heat and sound through proteins in a native (elementary) mode at the speed of sound. While sub-threshold in themselves they achieve resonance with similar phonon harmonics from other strategically self-assembled paramagnetic/diamagnetic constructs (PDCs) within the protein to enhance signal intensity several magnitudes (Kruglikov and Dertinger, 1994.) DNA, and other proteins posses a sophisticated capacity to electively combine such harmonics with other “noise”, i.e. stochastic resonance, to enhance their activity in support of cell function.
Dr. Gordon's paper, entitled “Protein Iteration and Cellular Response to Extrinsic Electromagnetic Forces,” is available on the Web site of The 2nd International Conference on Bioinformatics and Biomedical Engineering at http://www.icbbe.org/icbbe2008submission/website/icbbe/keynoteSpeakers.htm
--------------------------------------------------------------------------------
© 2008 Newswise. All Rights Reserved.
Wednesday, February 20, 2008
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Replenish Testosterone Naturally
Plant extracts favorably alter hormone metabolism and improve sexual desire in menThrough a variety of mechanisms, aging men suffer from the dual effects of having too little testosterone and excess estrogen. The result is a testosterone/ estrogen imbalance that can severely inhibit sexual desire and performance. In youth, low amounts of estrogen are used to turn off the powerful cell-stimulating effects of testosterone. As estrogen levels increase with age, testosterone cell stimulation may be locked in the "off" position, thus reducing sexual arousal and sensation and causing the common loss of libido so common in aging men. The genital/pelvic region is packed with testosterone receptors that are ultra-sensitive to free testosterone-induced sexual stimulation. Clinical studies using testosterone injections, creams or patches have not always provided a long-lasting libido enhancing effect in aging men. We now know why. Aging men sometimes convert testosterone to estrogen. The estrogen is then taken up by testosterone receptor sites in cells throughout the body. When an estrogen molecule occupies a testosterone receptor site on a cell membrane, it blocks the ability of serum testosterone to induce a healthy hormonal signal. It does not matter how much serum free testosterone is available if excess estrogen is competing for the same cellular receptor sites. Testosterone is a hormone responsible for sex drive in both men and women. For testosterone to promote youthful sexual interest, satisfaction and performance, it must be freely available to cell receptor sites in the brain, the nerves, muscles and genitals. As people age, testosterone becomes bound to serum globulin and is not available to the cell receptor sites were it is needed to initiate sex stimulating centers in the brain. The component in the blood that renders free testosterone inactive is called sex hormone-binding globulin (SHBG). Excess estrogen can increase the production of SHBG and block testosterone-receptor sites. This means there are two mechanisms by which excess estrogen interferes with sex dive in aging males. For testosterone to produce long-lasting libido enhancing effects, it must be kept in the "free" form in the bloodstream. Bound testosterone is not able to be picked up by testosterone receptors on cell membranes. For aging men, it is desirable to suppress excess levels of SHBG and estrogen while boosting free testosterone to the level of a young man. There is now a natural way of modulating testosterone and estrogen levels in aging men that does not require expensive prescription drugs. Restoring youthful hormone balance can have a significant impact on male sexuality. To reiterate, the hormone modulation objectives that most aging men need to facilitate sexual rejuvenation involves an increase in "free" testosterone coupled by a decrease in both estrogen and SHGD levels. Increasing testosterone by suppressing excess estrogen For many men, a safe and easy way to increase free testosterone is to prevent it from being converted (aromatized) into excess estrogen. Too much estrogen plays havoc with a man's sex life by binding to testosterone receptor sites and may contribute to the over-production of SHBG. SHBG binds free testosterone in a way that makes it unavailable to receptor sites in the brain, nerves and genitals. Estrogen overload is a serious problem in aging men. One report showed that estrogen levels of the average 54-year-old man are higher than those of the average 59-year-old woman. Estrogen is a necessary hormone for men, but too much causes a wide range of health problems. High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, thereby slowing the natural production of testosterone. Based on the multiple deleterious effects of excess estrogen in men, aggressive actions should be taken to reduce estrogen to a safe range. To determine if estrogen levels are too high, men are encouraged to have their blood tested for estradiol. If the blood test results show estradiol levels are greater than 30 pg/mL, men should consider radical lifestyle changes, and/or taking an aromatase-inhibiting nutrient or drug. A numerical example of the effects of a nutritional aromatase inhibitor can be seen on one of the subjects in the pilot studies whose initial serum estradiol level was a high 54 and free testosterone a moderately low 14.4. After only 30 days on a nutritional aromatase inhibitor, estradiol levels fell to 36 (from 54) and free testosterone levels increased to 22.5 (from 14.4). In this pilot study, funded by The Life Extension Foundation, 9 of 10 test subjects showed a significant decline in excess estrogen levels when several herbal extracts were combined. These kinds of results show how some men reduce excess estrogen while boosting free testosterone. Herbs and male sexual potency There are herbal extracts that have been shown to either increase or decrease testosterone levels. The New England Journal of Medicine (1998, 339;785-91) showed that an herbal preparation called PC Spes had the dual effect of suppressing testosterone and increasing estrogen and was therefore beneficial in the treatment of prostate cancer. Conversely, herbs that increase free testosterone and suppress excess estrogen are highly desirable for healthy men over age 40 who suffer the premature aging effects of a testosterone deficit, including loss of libido. We discuss some of these herbal extracts here. Chrysin A bioflavonoid called chrysin has shown potential as a natural aromatase-inhibitor. Chrysin can be extracted from various plants. Body builders have used it as a testosterone boosting supplement. The problem with chrysin is that because of its poor absorption into the bloodstream, it has not produced the testosterone enhancing effects users expect. In a study published in Biochemical Pharmacology (1999, Vol.58), the specific mechanisms of chrysin's absorption impairment were identified, which infers that the addition of a pepper extract (piperine) could significantly enhance the bioavailability of chrysin. Pilot studies have found that when chrysin is combined with piperine, reductions in serum estrogen (estradiol) and increases in total and free testosterone result in 30 days. Aromatase-inhibiting drugs are used to treat women with estrogen-dependant breast cancers. The rationale for this therapy is that estrogen is produced by fat cells via a process known as aromatization. Aging men often have excess aromatase enzyme activity, and the result is that too much of their testosterone is "aromatized" into estrogen. In a study published in the Journal of Steroid Biochemical Molecular Biology (1993;Vol 46, No 3), chrysin and 10 other flavonoids were compared to an aromatase-inhibiting drug (aminoglutethimide). The study tested the aromatase-inhibiting effects of these natural flavonoids (such as genistein, rutin, tea catechins, etc.) in human fat cell cultures. Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting drug. The scientists conducting the study concluded by stating that the aromatase-inhibiting effects of certain flavonoids may contribute to the cancer preventive effects of plant-based diets. Two recent studies have identified specific mechanisms by which chrysin inhibits aromatase in human cells. These studies demonstrate that chrysin is a more potent inhibitor of the aromatase enzyme than phyto-estrogens and other flavonoids that are known to have aromatase-inhibiting properties (Arch Pharm Res 1999 Jun;22(3):309-12; J Steroid Biochem Mol Biol 1997 Apr;61(3-6):107-15). The purpose of these studies was to ascertain which fruits and vegetables should be included in the diet of postmenopausal women to reduce the incidence of breast cancer. Excess levels of mutagenic forms of estrogen have been linked to a greater risk of breast cancer, and scientists are studying dietary means of naturally reducing levels of these dangerous estrogens. Flavonoids such as chrysin are of considerable interest because they suppress excess estrogen via their aromatase-inhibiting properties. While this cancer preventing effect is most important for women, inhibiting aromatase in aging men has tremendous potential for naturally suppressing excess estrogen while boosting low levels of testosterone to a youthful state. Since chrysin is not a patentable drug, don't expect to see a lot of human research documenting its effects. There are lots of FDA approved drugs that inhibit aromatase (such as Arimidex), and there is not much economic interest in finding natural ways of replacing these drugs. While prescription aromatase-inhibiting drugs are relatively free of side effects, aging men who are seeking to gain control over their sex hormone levels often prefer natural sources, rather than trying to convince a physician to prescribe a drug (such as Arimidex) that is not yet approved by the FDA as an anti-aging therapy. (Arimidex is prescribed to estrogen-dependant breast cancer patients to prevent testosterone and other hormones in the body from converting, i.e. aromatasing, into estrogen.) An advantage to using plant extracts to boost testosterone in lieu of drugs is that the plant extracts have ancillary health benefits. Chrysin, for example, is a potent antioxidant that possesses vitamin-like effects in the body. It has been shown to induce an anti-inflammatory effect, possibly through inhibition of the enzymes 5-lipoxygenase and cyclooxygenase inflammation pathways. Aging is being increasingly viewed as a pro-inflammatory process, and agents that inhibit chronic inflammation may protect against diseases as diverse as atherosclerosis, senility and aortic valve stenosis. Chrysin is one of many flavonoids being studied as a phyto-extract that may prevent some forms of cancer. If chrysin can boost free testosterone in the aging male by inhibiting the aromatase enzyme, this would provide men with a low cost natural supplement that could provide the dual anti-aging benefits of testosterone replacement and aromatase-inhibiting drug therapy. As previously discussed, boosting free testosterone levels can have a dramatic effect on sex drive, performance and satisfaction. Pilot studies indicate that chrysin increases total and free testosterone levels in the majority of men who take it with piperine. Chrysin has one other property that could add to its libido-enhancing potential. A major cause of sexual dissatisfaction among men is work-related stress and anxiety. Another problem some men have is "sexual performance anxiety" that prevents them from being able to achieve erections when they are expected to. In a study published in Pharmacology Biochemistry and Behavior (1994, Vol 47), mice were injected with diazepam (Valium), chrysin or placebo to evaluate the effects these substances had on anxiety and performance levels. Chrysin was shown to produce anti-anxiety effects comparable with diazepam, but without sedation and muscle relaxation. In other words, chrysin produced a relaxing effect in the brain, but with no impairment of motor activity. The mechanism of action of chrysin was compared to diazepam, and it was shown that unlike diazepam, chrysin can reduce anxiety without inducing the common side-effects associated with benzodiazepine drugs. A common problem with benzodiazepine drugs is memory impairment. In a study published in a 1997 issue of Pharmacology Biochemistry and Behavior (Vol 58, No 4), chrysin displayed potent anti-anxiety effects in rats, but did not interfere with cognitive performance. In this study, diazepam was shown to inhibit neurological function, but chrysin (and other anti-anxiety flavonoids) had no effect on training or test session performance. The scientists conducting this study pointed out that chrysin selectively inhibits anxiety in the brain but, unlike diazepam, does not induce the cognitive impairment. Chrysin may therefore offer libido-enhancing effects in the aging male by: - Increasing free testosterone, - Decreasing excess estrogen, - Producing a safe anti-anxiety effect. Chrysin is being sold to body builders by commercial supplement companies that do not know if their product is favorably modulating testosterone and estrogen levels in men. The Life Extension Foundation, on the other hand, has conducted meticulous studies to evaluate the effects of chrysin (combined with piperine to facilitate absorption) on aging men. These studies have produced some impressive preliminary data, and ongoing research will be reported in future issues of Life Extension magazine. Nettle About 90% of testosterone is produced by the testes, the remainder by the adrenal glands. Testosterone functions as an aphrodisiac hormone in brains cells, and as an anabolic hormone in the development of bone and skeletal muscle. But testosterone that becomes bound to serum globulin is not available to cell receptor sites and fails to induce a libido effect. It is, therefore, desirable to increase levels of "free testosterone" in order to ignite sexual arousal in the brain. As discussed already, a hormone that controls levels of free testosterone is called sex hormone-binding globulin (SHBG). When testosterone binds to SHBG, it loses its biological activity and becomes known as "bound testosterone," as opposed to the desirable "free testosterone." As men age past year 45, SHBG's binding capacity increases almost dramatically-by 40% on average-and coincides with the age-associated loss of libido. Some studies show that the decline in sexual interest with advancing age is not always due to the amount of testosterone produced, but rather to the increased binding of testosterone to globulin by SHBG. This explains why some older men who are on testosterone replacement therapy do not report a long-term aphrodisiac effect. That is, the artificially administered testosterone becomes bound by SHBG, and is not bioavailable to cellular receptor sites where it would normally produce a libido-enhancing effect. It should be noted that the liver also causes testosterone to bind to globulin. This liver-induced binding of testosterone is worsened by the use of sedatives, anti-hypertensives, tranquilizers and alcoholic beverages. The overuse of drugs and alcohol could explain why some men do not experience a libido-enhancing effect when consuming drugs and plant-based aphrodisiacs. An interesting review, "How Desire Dies" (Nature, 381/6584, 1996), discusses how frequently prescribed drugs, such as beta-blockers and antidepressants, cause sexual dysfunction. Prescription drugs of all sorts have been linked to inhibition of libido. Logically, one way of increasing libido in older men would be to block the testosterone-binding effects of SHBG. This would leave more testosterone in its free, sexually activating form. A highly concentrated extract from the nettle root provides a unique mechanism for increasing levels of free testosterone. Recent European research has identified constituents of nettle root that bind to SHBG in place of testosterone, thus reducing SHBG's binding of free testosterone. As the authors of one study state, these constituents of nettle root "may influence the blood level of free, i.e. active, steroid hormones by displacing them from the SHBG bindings site." The prostate gland also benefits from nettle root. In Germany, nettle root has been used as a treatment for benign prostatic hyperplasia (enlargement of the prostate gland) for decades. A metabolite of testosterone called dihydrotestosterone (DHT) stimulates prostate growth, leading to enlargement. Nettle root inhibits the binding of DHT to attachment sites on the prostate membrane. Nettle extracts also inhibit enzymes such as 5 alpha reductase that cause testosterone to convert to DHT. It is the DHT metabolite of testosterone that is known to cause benign prostate enlargement, excess facial hair and hair loss at the top of the head. Muira puama French scientists have identified an herbal extract that has shown libido enhancing effects in two human clinical studies. Muira puama comes from the stems and roots of the Ptychopetalum olacoides plant, and is widely used in the Amazon region of South America as an aphrodisiac, tonic and cure for rheumatism and muscle paralysis. Muira puama has been the subject of two published clinical studies conducted by Dr. Jacques Waynberg, an eminent medical sexologist and author of 10 books on the subject. The first study, conducted at the Institute of Sexology in Paris under Waynberg's supervision, was reported in the November 1994 issue of The American Journal of Natural Medicine. The study population consisted of 262 men complaining of lack of sexual desire, or inability to attain or maintain erection. After two weeks, 62 percent of patients with loss of libido rated the treatment as having a dynamic effect, while 52 percent of patients with erectile dysfunction rated the treatment as beneficial. The article goes on to compare muira puama favorably to yohimbine, stating, "Muira puama may provide better results than yohimbine without side effects." Dr. Waynberg's second study, entitled "Male Sexual Asthenia," focused on sexual difficulties associated with asthenia, a deficiency state characterized by fatigue, loss of strength, or debility, all symptoms of a testosterone deficiency. The study population consisted of 100 men over 18 years of age who complained of impotence or loss of libido, or both. A total of 94 men completed the study and were evaluated. Muira puama treatment led to significantly increased frequency of intercourse for 66% of couples. Of the 46 men who complained of loss of desire, 70% reported intensification of libido. The stability of erection during intercourse was restored in 55% of patients and 66% of men reported a reduction in fatigue. Other beneficial effects included improvement in sleep and morning erections. Treatment with muira puama was much more effective in cases with the least psychosomatic involvement. Of the 26 men diagnosed with common sexual asthenia without noticeable sign of psychosomatic disorder, the treatment was effective for asthenia in 100% of cases, the lack of libido in 85% of cases, and for inability of coital erection in 90% of cases. The latter finding confirms that broad tonic action of muira puama on conditions of fatigue and stress related sexual dysfunction. Since muira puama is not an artificial stimulant, it fortifies the system over a period of time. Some men report increased vitality within two weeks, while the full effects build over several weeks. Dr. Waynberg notes that his toxicology studies and observations corroborate the conclusions of the scientific literature on the absence of toxicity of muira puama, which is well tolerated by men in general good health. One of the earliest scientific studies of muira puama was conducted by another French doctor, Dr. Rebourgeon. His research found the plant to be effective in "gastrointestinal and circulatory asthenia as well as impotence." Three of the most respected scientific authorities on medical herbalism recommend muira puama. In newly published books, James Duke, Ph.D., Chief of the United States Department of Agriculture's Medical Plant Laboratory, and Michael Murray, M.D., recommend muira puama for erectile dysfunction or lack of libido. In addition, Daniel Mowrey, Ph.D., states the following in his book Herbal Tonic Therapies (p. 358): Few in number are the plants that seem to have a reliable reputation as true aphrodisiacs. . . . Snake oil remedies abound, and confusion, dishonesty and hyped-up placebo razzmatazz carry the day. Out of this mess, one plant, virtually unknown to most Americans, appears to have risen above the competition. The plant is called muira puama. And though not much is known scientifically about the plant, all indications would lead one to believe that here is a material with the potential for making an important and significant contribution to the health of the male reproductive system. Based on the clinical reports documenting the libido and energy enhancing effects of muira puama, it is possible that this herb induces these positive changes by favorably altering the hormone balance in aging men, i.e. increases free testosterone and/or suppresses excess estrogen. Putting it all together Enhanced sexual enjoyment is of paramount importance to a great many people, increasingly so as we age. An enormous amount of published data documents the libido-enhancing effects that occur when testosterone is restored to a youthful level. Testosterone is much more than a sex hormone. There are testosterone receptor sites in cells throughout the body, most notably in the brain and heart. Youthful protein synthesis for maintaining muscle mass and bone formation requires testosterone. Testosterone improves oxygen uptake throughout the body, helps control blood sugar, regulate cholesterol and maintain immune surveillance. The body requires testosterone to maintain youthful cardiac output and neurological function. Men suffering from depression often have lower levels of testosterone than control subjects. For some men, elevating free testosterone levels could prove to be an effective anti-depressant therapy. There is a scientific basis for free testosterone levels being measured in men suffering from depression and replacement therapy initiated if free testosterone levels are low normal or below normal. One of the most misunderstood hormones is testosterone. Body builders tarnished the reputation of testosterone by putting large amounts of synthetic testosterone drugs into their young bodies. Synthetic testosterone abuse can produce detrimental effects, but this has nothing to do with the benefits a man over age 40 can enjoy by properly restoring his natural testosterone to a youthful level. The many health benefits of hormone modulation therapy in aging men is the subject of these books authored by highly respected medical doctors: Vitality and Potency, by Jonathan V. Wright, M.D. and Lane Lenard, Ph.D. and The Testosterone Syndrome, co-authored by Eugene Shippen, M.D. These books provide meticulous molecular details, along with many case histories relating to the sexual enhancing effects that occur when free testosterone is increased beyond normal "middle-aged" levels. In the November 1999 issue of this publication, an in-depth article described complex pharmaceutical methods of increasing free testosterone using FDA approved drugs. Many members, however, inquired about natural ways of increasing testosterone while suppressing excess estrogen. Ongoing research at The Life Extension Foundation has resulted in several plant extracts being identified that appear to increase free testosterone and suppress excess estrogen in most men. In addition, clinical studies on one of these plant extracts indicates a significant libido-enhancing effect in the majority of men in placebo-controlled trials. Men over age 40 now have the option of using testosterone patches or creams that need to be prescribed by their physician, or they can try a new combination of plant extracts that have shown promising results. Results from published studies continue to substantiate the critical role that testosterone plays in protecting against premature aging. Life Extension magazine readers will be kept informed on scientifically validated testosterone enhancing strategies in future issues. Excess Estrogen and age-associated immune dysfunction It is well known that aging results in the shrinkage of the thymus gland, along with a reduction in the secretion of thymic hormones and T-cells, all of which are essential for maintaining youthful immune synchronization. A study published in the journal Immnological Reviews (1997, Vol 160) showed that excess estrogen may be the primary sex hormone responsible for age-induced thymic involution (shrinkage) and age-associated immune dysfunction. The name of this extensive study was "Thymic Aging and T-Cell Regeneration," and it suggested that hormone modulation was one way of accomplishing thymic regeneration. A chapter from the 1998 textbook Principles and Practices of Geriatric Medicine entitled "Immunity and Aging" also discussed the role sex steroid hormones play in thymic involution. These studies suggest that restoring youthful sex hormone profiles could assist in protecting against immune impairment caused by the shrinking thymus gland. Hormone modulating nutrients: the studies As described in the November 1999 issue of Life Extension magazine, there are testosterone drugs and estrogen suppressing drugs that can be prescribed by your doctor. Understandably, however, some people do not want to use drugs if nutrients can accomplish the same objective. In order to ascertain the safety and efficacy of various nutrients that are purported to modulate male hormone levels, The Life Extension Foundation has been sponsoring clinical studies to assess the effects of specific supplements on blood levels of testosterone, estrogen, SHBG, etc. The results from the first pilot study showed that nine out of 10 men experienced a significant reduction in serum estradiol (estrogen) levels after only thirty days, compared to baseline. In this brief study, total testosterone increased in seven out of 10 men, but free testosterone increased in only four of the 10 men studied. Other blood parameters were not statistically altered. A more comprehensive study incorporating a different combination of nutrients resulted in 8 out of 8 men experiencing increases in free testosterone while levels of the undesirable SHBG declined in seven out of eight men, compared to baseline. Estrogen and other blood parameters were not significantly altered in this study. A third study was undertaken to evaluate still another combination of nutrients. It revealed that after thirty days, 12 out of 17 men experienced an increase in total testosterone and 11 out of 17 showed an increase in free testosterone, compared to baseline. Again, other blood parameters were not significantly altered. Clinical trials are ongoing, and are expected to continue into early year 2000. Medical Testing For the average male over age 40, increasing free testosterone can restore the sexual fire of youth. The only downside to increasing free testosterone levels to those of a healthy 21-year-old is the potential effects it may have on men with prostate cancer. Before embarking on a testosterone-enhancement program a baseline blood PSA test and a digital rectal exam taken to rule out existing prostate cancer. When using testosterone drugs, PSA blood tests should be taken every 30-45 days for the first five months to rule out hidden prostate cancer. When using slower acting testosterone boosting nutritional supplements, PSA testing can be reduced to every 60-90 days for the first eight months. Remember, the preponderance of the published literature shows that increasing free testosterone does not increase the risk of cancer in healthy men, but those with existing prostate cancer should avoid testosterone boosting drugs and supplements.
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Replenish Testosterone Naturally
Plant extracts favorably alter hormone metabolism and improve sexual desire in menThrough a variety of mechanisms, aging men suffer from the dual effects of having too little testosterone and excess estrogen. The result is a testosterone/ estrogen imbalance that can severely inhibit sexual desire and performance. In youth, low amounts of estrogen are used to turn off the powerful cell-stimulating effects of testosterone. As estrogen levels increase with age, testosterone cell stimulation may be locked in the "off" position, thus reducing sexual arousal and sensation and causing the common loss of libido so common in aging men. The genital/pelvic region is packed with testosterone receptors that are ultra-sensitive to free testosterone-induced sexual stimulation. Clinical studies using testosterone injections, creams or patches have not always provided a long-lasting libido enhancing effect in aging men. We now know why. Aging men sometimes convert testosterone to estrogen. The estrogen is then taken up by testosterone receptor sites in cells throughout the body. When an estrogen molecule occupies a testosterone receptor site on a cell membrane, it blocks the ability of serum testosterone to induce a healthy hormonal signal. It does not matter how much serum free testosterone is available if excess estrogen is competing for the same cellular receptor sites. Testosterone is a hormone responsible for sex drive in both men and women. For testosterone to promote youthful sexual interest, satisfaction and performance, it must be freely available to cell receptor sites in the brain, the nerves, muscles and genitals. As people age, testosterone becomes bound to serum globulin and is not available to the cell receptor sites were it is needed to initiate sex stimulating centers in the brain. The component in the blood that renders free testosterone inactive is called sex hormone-binding globulin (SHBG). Excess estrogen can increase the production of SHBG and block testosterone-receptor sites. This means there are two mechanisms by which excess estrogen interferes with sex dive in aging males. For testosterone to produce long-lasting libido enhancing effects, it must be kept in the "free" form in the bloodstream. Bound testosterone is not able to be picked up by testosterone receptors on cell membranes. For aging men, it is desirable to suppress excess levels of SHBG and estrogen while boosting free testosterone to the level of a young man. There is now a natural way of modulating testosterone and estrogen levels in aging men that does not require expensive prescription drugs. Restoring youthful hormone balance can have a significant impact on male sexuality. To reiterate, the hormone modulation objectives that most aging men need to facilitate sexual rejuvenation involves an increase in "free" testosterone coupled by a decrease in both estrogen and SHGD levels. Increasing testosterone by suppressing excess estrogen For many men, a safe and easy way to increase free testosterone is to prevent it from being converted (aromatized) into excess estrogen. Too much estrogen plays havoc with a man's sex life by binding to testosterone receptor sites and may contribute to the over-production of SHBG. SHBG binds free testosterone in a way that makes it unavailable to receptor sites in the brain, nerves and genitals. Estrogen overload is a serious problem in aging men. One report showed that estrogen levels of the average 54-year-old man are higher than those of the average 59-year-old woman. Estrogen is a necessary hormone for men, but too much causes a wide range of health problems. High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, thereby slowing the natural production of testosterone. Based on the multiple deleterious effects of excess estrogen in men, aggressive actions should be taken to reduce estrogen to a safe range. To determine if estrogen levels are too high, men are encouraged to have their blood tested for estradiol. If the blood test results show estradiol levels are greater than 30 pg/mL, men should consider radical lifestyle changes, and/or taking an aromatase-inhibiting nutrient or drug. A numerical example of the effects of a nutritional aromatase inhibitor can be seen on one of the subjects in the pilot studies whose initial serum estradiol level was a high 54 and free testosterone a moderately low 14.4. After only 30 days on a nutritional aromatase inhibitor, estradiol levels fell to 36 (from 54) and free testosterone levels increased to 22.5 (from 14.4). In this pilot study, funded by The Life Extension Foundation, 9 of 10 test subjects showed a significant decline in excess estrogen levels when several herbal extracts were combined. These kinds of results show how some men reduce excess estrogen while boosting free testosterone. Herbs and male sexual potency There are herbal extracts that have been shown to either increase or decrease testosterone levels. The New England Journal of Medicine (1998, 339;785-91) showed that an herbal preparation called PC Spes had the dual effect of suppressing testosterone and increasing estrogen and was therefore beneficial in the treatment of prostate cancer. Conversely, herbs that increase free testosterone and suppress excess estrogen are highly desirable for healthy men over age 40 who suffer the premature aging effects of a testosterone deficit, including loss of libido. We discuss some of these herbal extracts here. Chrysin A bioflavonoid called chrysin has shown potential as a natural aromatase-inhibitor. Chrysin can be extracted from various plants. Body builders have used it as a testosterone boosting supplement. The problem with chrysin is that because of its poor absorption into the bloodstream, it has not produced the testosterone enhancing effects users expect. In a study published in Biochemical Pharmacology (1999, Vol.58), the specific mechanisms of chrysin's absorption impairment were identified, which infers that the addition of a pepper extract (piperine) could significantly enhance the bioavailability of chrysin. Pilot studies have found that when chrysin is combined with piperine, reductions in serum estrogen (estradiol) and increases in total and free testosterone result in 30 days. Aromatase-inhibiting drugs are used to treat women with estrogen-dependant breast cancers. The rationale for this therapy is that estrogen is produced by fat cells via a process known as aromatization. Aging men often have excess aromatase enzyme activity, and the result is that too much of their testosterone is "aromatized" into estrogen. In a study published in the Journal of Steroid Biochemical Molecular Biology (1993;Vol 46, No 3), chrysin and 10 other flavonoids were compared to an aromatase-inhibiting drug (aminoglutethimide). The study tested the aromatase-inhibiting effects of these natural flavonoids (such as genistein, rutin, tea catechins, etc.) in human fat cell cultures. Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting drug. The scientists conducting the study concluded by stating that the aromatase-inhibiting effects of certain flavonoids may contribute to the cancer preventive effects of plant-based diets. Two recent studies have identified specific mechanisms by which chrysin inhibits aromatase in human cells. These studies demonstrate that chrysin is a more potent inhibitor of the aromatase enzyme than phyto-estrogens and other flavonoids that are known to have aromatase-inhibiting properties (Arch Pharm Res 1999 Jun;22(3):309-12; J Steroid Biochem Mol Biol 1997 Apr;61(3-6):107-15). The purpose of these studies was to ascertain which fruits and vegetables should be included in the diet of postmenopausal women to reduce the incidence of breast cancer. Excess levels of mutagenic forms of estrogen have been linked to a greater risk of breast cancer, and scientists are studying dietary means of naturally reducing levels of these dangerous estrogens. Flavonoids such as chrysin are of considerable interest because they suppress excess estrogen via their aromatase-inhibiting properties. While this cancer preventing effect is most important for women, inhibiting aromatase in aging men has tremendous potential for naturally suppressing excess estrogen while boosting low levels of testosterone to a youthful state. Since chrysin is not a patentable drug, don't expect to see a lot of human research documenting its effects. There are lots of FDA approved drugs that inhibit aromatase (such as Arimidex), and there is not much economic interest in finding natural ways of replacing these drugs. While prescription aromatase-inhibiting drugs are relatively free of side effects, aging men who are seeking to gain control over their sex hormone levels often prefer natural sources, rather than trying to convince a physician to prescribe a drug (such as Arimidex) that is not yet approved by the FDA as an anti-aging therapy. (Arimidex is prescribed to estrogen-dependant breast cancer patients to prevent testosterone and other hormones in the body from converting, i.e. aromatasing, into estrogen.) An advantage to using plant extracts to boost testosterone in lieu of drugs is that the plant extracts have ancillary health benefits. Chrysin, for example, is a potent antioxidant that possesses vitamin-like effects in the body. It has been shown to induce an anti-inflammatory effect, possibly through inhibition of the enzymes 5-lipoxygenase and cyclooxygenase inflammation pathways. Aging is being increasingly viewed as a pro-inflammatory process, and agents that inhibit chronic inflammation may protect against diseases as diverse as atherosclerosis, senility and aortic valve stenosis. Chrysin is one of many flavonoids being studied as a phyto-extract that may prevent some forms of cancer. If chrysin can boost free testosterone in the aging male by inhibiting the aromatase enzyme, this would provide men with a low cost natural supplement that could provide the dual anti-aging benefits of testosterone replacement and aromatase-inhibiting drug therapy. As previously discussed, boosting free testosterone levels can have a dramatic effect on sex drive, performance and satisfaction. Pilot studies indicate that chrysin increases total and free testosterone levels in the majority of men who take it with piperine. Chrysin has one other property that could add to its libido-enhancing potential. A major cause of sexual dissatisfaction among men is work-related stress and anxiety. Another problem some men have is "sexual performance anxiety" that prevents them from being able to achieve erections when they are expected to. In a study published in Pharmacology Biochemistry and Behavior (1994, Vol 47), mice were injected with diazepam (Valium), chrysin or placebo to evaluate the effects these substances had on anxiety and performance levels. Chrysin was shown to produce anti-anxiety effects comparable with diazepam, but without sedation and muscle relaxation. In other words, chrysin produced a relaxing effect in the brain, but with no impairment of motor activity. The mechanism of action of chrysin was compared to diazepam, and it was shown that unlike diazepam, chrysin can reduce anxiety without inducing the common side-effects associated with benzodiazepine drugs. A common problem with benzodiazepine drugs is memory impairment. In a study published in a 1997 issue of Pharmacology Biochemistry and Behavior (Vol 58, No 4), chrysin displayed potent anti-anxiety effects in rats, but did not interfere with cognitive performance. In this study, diazepam was shown to inhibit neurological function, but chrysin (and other anti-anxiety flavonoids) had no effect on training or test session performance. The scientists conducting this study pointed out that chrysin selectively inhibits anxiety in the brain but, unlike diazepam, does not induce the cognitive impairment. Chrysin may therefore offer libido-enhancing effects in the aging male by: - Increasing free testosterone, - Decreasing excess estrogen, - Producing a safe anti-anxiety effect. Chrysin is being sold to body builders by commercial supplement companies that do not know if their product is favorably modulating testosterone and estrogen levels in men. The Life Extension Foundation, on the other hand, has conducted meticulous studies to evaluate the effects of chrysin (combined with piperine to facilitate absorption) on aging men. These studies have produced some impressive preliminary data, and ongoing research will be reported in future issues of Life Extension magazine. Nettle About 90% of testosterone is produced by the testes, the remainder by the adrenal glands. Testosterone functions as an aphrodisiac hormone in brains cells, and as an anabolic hormone in the development of bone and skeletal muscle. But testosterone that becomes bound to serum globulin is not available to cell receptor sites and fails to induce a libido effect. It is, therefore, desirable to increase levels of "free testosterone" in order to ignite sexual arousal in the brain. As discussed already, a hormone that controls levels of free testosterone is called sex hormone-binding globulin (SHBG). When testosterone binds to SHBG, it loses its biological activity and becomes known as "bound testosterone," as opposed to the desirable "free testosterone." As men age past year 45, SHBG's binding capacity increases almost dramatically-by 40% on average-and coincides with the age-associated loss of libido. Some studies show that the decline in sexual interest with advancing age is not always due to the amount of testosterone produced, but rather to the increased binding of testosterone to globulin by SHBG. This explains why some older men who are on testosterone replacement therapy do not report a long-term aphrodisiac effect. That is, the artificially administered testosterone becomes bound by SHBG, and is not bioavailable to cellular receptor sites where it would normally produce a libido-enhancing effect. It should be noted that the liver also causes testosterone to bind to globulin. This liver-induced binding of testosterone is worsened by the use of sedatives, anti-hypertensives, tranquilizers and alcoholic beverages. The overuse of drugs and alcohol could explain why some men do not experience a libido-enhancing effect when consuming drugs and plant-based aphrodisiacs. An interesting review, "How Desire Dies" (Nature, 381/6584, 1996), discusses how frequently prescribed drugs, such as beta-blockers and antidepressants, cause sexual dysfunction. Prescription drugs of all sorts have been linked to inhibition of libido. Logically, one way of increasing libido in older men would be to block the testosterone-binding effects of SHBG. This would leave more testosterone in its free, sexually activating form. A highly concentrated extract from the nettle root provides a unique mechanism for increasing levels of free testosterone. Recent European research has identified constituents of nettle root that bind to SHBG in place of testosterone, thus reducing SHBG's binding of free testosterone. As the authors of one study state, these constituents of nettle root "may influence the blood level of free, i.e. active, steroid hormones by displacing them from the SHBG bindings site." The prostate gland also benefits from nettle root. In Germany, nettle root has been used as a treatment for benign prostatic hyperplasia (enlargement of the prostate gland) for decades. A metabolite of testosterone called dihydrotestosterone (DHT) stimulates prostate growth, leading to enlargement. Nettle root inhibits the binding of DHT to attachment sites on the prostate membrane. Nettle extracts also inhibit enzymes such as 5 alpha reductase that cause testosterone to convert to DHT. It is the DHT metabolite of testosterone that is known to cause benign prostate enlargement, excess facial hair and hair loss at the top of the head. Muira puama French scientists have identified an herbal extract that has shown libido enhancing effects in two human clinical studies. Muira puama comes from the stems and roots of the Ptychopetalum olacoides plant, and is widely used in the Amazon region of South America as an aphrodisiac, tonic and cure for rheumatism and muscle paralysis. Muira puama has been the subject of two published clinical studies conducted by Dr. Jacques Waynberg, an eminent medical sexologist and author of 10 books on the subject. The first study, conducted at the Institute of Sexology in Paris under Waynberg's supervision, was reported in the November 1994 issue of The American Journal of Natural Medicine. The study population consisted of 262 men complaining of lack of sexual desire, or inability to attain or maintain erection. After two weeks, 62 percent of patients with loss of libido rated the treatment as having a dynamic effect, while 52 percent of patients with erectile dysfunction rated the treatment as beneficial. The article goes on to compare muira puama favorably to yohimbine, stating, "Muira puama may provide better results than yohimbine without side effects." Dr. Waynberg's second study, entitled "Male Sexual Asthenia," focused on sexual difficulties associated with asthenia, a deficiency state characterized by fatigue, loss of strength, or debility, all symptoms of a testosterone deficiency. The study population consisted of 100 men over 18 years of age who complained of impotence or loss of libido, or both. A total of 94 men completed the study and were evaluated. Muira puama treatment led to significantly increased frequency of intercourse for 66% of couples. Of the 46 men who complained of loss of desire, 70% reported intensification of libido. The stability of erection during intercourse was restored in 55% of patients and 66% of men reported a reduction in fatigue. Other beneficial effects included improvement in sleep and morning erections. Treatment with muira puama was much more effective in cases with the least psychosomatic involvement. Of the 26 men diagnosed with common sexual asthenia without noticeable sign of psychosomatic disorder, the treatment was effective for asthenia in 100% of cases, the lack of libido in 85% of cases, and for inability of coital erection in 90% of cases. The latter finding confirms that broad tonic action of muira puama on conditions of fatigue and stress related sexual dysfunction. Since muira puama is not an artificial stimulant, it fortifies the system over a period of time. Some men report increased vitality within two weeks, while the full effects build over several weeks. Dr. Waynberg notes that his toxicology studies and observations corroborate the conclusions of the scientific literature on the absence of toxicity of muira puama, which is well tolerated by men in general good health. One of the earliest scientific studies of muira puama was conducted by another French doctor, Dr. Rebourgeon. His research found the plant to be effective in "gastrointestinal and circulatory asthenia as well as impotence." Three of the most respected scientific authorities on medical herbalism recommend muira puama. In newly published books, James Duke, Ph.D., Chief of the United States Department of Agriculture's Medical Plant Laboratory, and Michael Murray, M.D., recommend muira puama for erectile dysfunction or lack of libido. In addition, Daniel Mowrey, Ph.D., states the following in his book Herbal Tonic Therapies (p. 358): Few in number are the plants that seem to have a reliable reputation as true aphrodisiacs. . . . Snake oil remedies abound, and confusion, dishonesty and hyped-up placebo razzmatazz carry the day. Out of this mess, one plant, virtually unknown to most Americans, appears to have risen above the competition. The plant is called muira puama. And though not much is known scientifically about the plant, all indications would lead one to believe that here is a material with the potential for making an important and significant contribution to the health of the male reproductive system. Based on the clinical reports documenting the libido and energy enhancing effects of muira puama, it is possible that this herb induces these positive changes by favorably altering the hormone balance in aging men, i.e. increases free testosterone and/or suppresses excess estrogen. Putting it all together Enhanced sexual enjoyment is of paramount importance to a great many people, increasingly so as we age. An enormous amount of published data documents the libido-enhancing effects that occur when testosterone is restored to a youthful level. Testosterone is much more than a sex hormone. There are testosterone receptor sites in cells throughout the body, most notably in the brain and heart. Youthful protein synthesis for maintaining muscle mass and bone formation requires testosterone. Testosterone improves oxygen uptake throughout the body, helps control blood sugar, regulate cholesterol and maintain immune surveillance. The body requires testosterone to maintain youthful cardiac output and neurological function. Men suffering from depression often have lower levels of testosterone than control subjects. For some men, elevating free testosterone levels could prove to be an effective anti-depressant therapy. There is a scientific basis for free testosterone levels being measured in men suffering from depression and replacement therapy initiated if free testosterone levels are low normal or below normal. One of the most misunderstood hormones is testosterone. Body builders tarnished the reputation of testosterone by putting large amounts of synthetic testosterone drugs into their young bodies. Synthetic testosterone abuse can produce detrimental effects, but this has nothing to do with the benefits a man over age 40 can enjoy by properly restoring his natural testosterone to a youthful level. The many health benefits of hormone modulation therapy in aging men is the subject of these books authored by highly respected medical doctors: Vitality and Potency, by Jonathan V. Wright, M.D. and Lane Lenard, Ph.D. and The Testosterone Syndrome, co-authored by Eugene Shippen, M.D. These books provide meticulous molecular details, along with many case histories relating to the sexual enhancing effects that occur when free testosterone is increased beyond normal "middle-aged" levels. In the November 1999 issue of this publication, an in-depth article described complex pharmaceutical methods of increasing free testosterone using FDA approved drugs. Many members, however, inquired about natural ways of increasing testosterone while suppressing excess estrogen. Ongoing research at The Life Extension Foundation has resulted in several plant extracts being identified that appear to increase free testosterone and suppress excess estrogen in most men. In addition, clinical studies on one of these plant extracts indicates a significant libido-enhancing effect in the majority of men in placebo-controlled trials. Men over age 40 now have the option of using testosterone patches or creams that need to be prescribed by their physician, or they can try a new combination of plant extracts that have shown promising results. Results from published studies continue to substantiate the critical role that testosterone plays in protecting against premature aging. Life Extension magazine readers will be kept informed on scientifically validated testosterone enhancing strategies in future issues. Excess Estrogen and age-associated immune dysfunction It is well known that aging results in the shrinkage of the thymus gland, along with a reduction in the secretion of thymic hormones and T-cells, all of which are essential for maintaining youthful immune synchronization. A study published in the journal Immnological Reviews (1997, Vol 160) showed that excess estrogen may be the primary sex hormone responsible for age-induced thymic involution (shrinkage) and age-associated immune dysfunction. The name of this extensive study was "Thymic Aging and T-Cell Regeneration," and it suggested that hormone modulation was one way of accomplishing thymic regeneration. A chapter from the 1998 textbook Principles and Practices of Geriatric Medicine entitled "Immunity and Aging" also discussed the role sex steroid hormones play in thymic involution. These studies suggest that restoring youthful sex hormone profiles could assist in protecting against immune impairment caused by the shrinking thymus gland. Hormone modulating nutrients: the studies As described in the November 1999 issue of Life Extension magazine, there are testosterone drugs and estrogen suppressing drugs that can be prescribed by your doctor. Understandably, however, some people do not want to use drugs if nutrients can accomplish the same objective. In order to ascertain the safety and efficacy of various nutrients that are purported to modulate male hormone levels, The Life Extension Foundation has been sponsoring clinical studies to assess the effects of specific supplements on blood levels of testosterone, estrogen, SHBG, etc. The results from the first pilot study showed that nine out of 10 men experienced a significant reduction in serum estradiol (estrogen) levels after only thirty days, compared to baseline. In this brief study, total testosterone increased in seven out of 10 men, but free testosterone increased in only four of the 10 men studied. Other blood parameters were not statistically altered. A more comprehensive study incorporating a different combination of nutrients resulted in 8 out of 8 men experiencing increases in free testosterone while levels of the undesirable SHBG declined in seven out of eight men, compared to baseline. Estrogen and other blood parameters were not significantly altered in this study. A third study was undertaken to evaluate still another combination of nutrients. It revealed that after thirty days, 12 out of 17 men experienced an increase in total testosterone and 11 out of 17 showed an increase in free testosterone, compared to baseline. Again, other blood parameters were not significantly altered. Clinical trials are ongoing, and are expected to continue into early year 2000. Medical Testing For the average male over age 40, increasing free testosterone can restore the sexual fire of youth. The only downside to increasing free testosterone levels to those of a healthy 21-year-old is the potential effects it may have on men with prostate cancer. Before embarking on a testosterone-enhancement program a baseline blood PSA test and a digital rectal exam taken to rule out existing prostate cancer. When using testosterone drugs, PSA blood tests should be taken every 30-45 days for the first five months to rule out hidden prostate cancer. When using slower acting testosterone boosting nutritional supplements, PSA testing can be reduced to every 60-90 days for the first eight months. Remember, the preponderance of the published literature shows that increasing free testosterone does not increase the risk of cancer in healthy men, but those with existing prostate cancer should avoid testosterone boosting drugs and supplements.
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PABA
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DMAE and PABA
An Alternative to Gerovital (GH3), the Romanian Youth Drug
By Ward Dean, MD
In Romania, Gerovital, or GH3, has been used for over 50 years to help people look and feel younger. It has attracted thousands of people each year to the spas of Romania and Western Europe where this therapy has been widely used. GH3 is a modification of the local anesthetic, procaine. It was developed for anti-aging uses by Professor Ana Aslan in Romania in the 1940s (Fig. 1). The discovery of procaines potential anti-aging properties was a serendipitous finding. Prof. Aslan was experimenting with the pain-relieving effects of procaine on patients with severe arthritis by injecting it into the arteries (!) which supplied blood to the area of the affected joints. She logically theorized that procaine, being an anesthetic, would relieve the joint pain. She was surprised to find that in addition to dramatic relief of joint pains, many patients also noted (1) improved memory, (2) less depression, (3) more energy, (4) restoration of normal hair color, (5) improved skin tone, and (6) a generalized feeling of well-being. (1)
These provocative results encouraged Prof. Aslan to carry out additional studies to test the effects of procaine on thousands of people. She did this at the Romanian National Institute of Gerontology and Geriatrics which she founded in 1950 — the first government-sponsored aging research institute in the world. Aslan found that by adding benzoic acid as a preservative, and potassium metabisulfite as an antioxidant, the procaine molecule was stabilized, and the effects were even more dramatic than with procaine alone. She called her improved form of procaine Gerovital, or GH3. She later added pyridoxine (vitamin B6), mesoinositol, and glutamic acid to this formula, to form yet another version called Aslavital. Aslavital was reported to have even more powerful and beneficial effects on memory, atherosclerosis, and other degenerative conditions than the original Gerovital H3. (2)
Gerovital
H3 is approved by the Romanian equivalent of the FDA for use in the treatment of numerous diseases, including: (1) prevention and treatment of the aging process; (2) depression; (3) arthritis; (4) asthma; (5) gastric and duodenal ulcers, (6) osteoporosis, and many other conditions.
In 1987, I traveled to Romania to attend and present a paper at the Romanian National Congress of Gerontology and Geriatrics (Dean). (3) I was interested in learning more
about Gerovital and Aslavital — to see first-hand how it was administered, meet patients undergoing the therapy, and review the scientific studies that had been performed. I was impressed by the body of scientific research that supported the use of procaine, Gerovital H3, and Aslavital as prophylactic and therapeutic agents against the aging process.
How Does Gerovital Work?
Procaine, as Gerovital H3 and Aslavital, has numerous documented mechanisms of action. These include (1) inhibition of monoamine oxidase (an enzyme in the brain which increases with age); (4,5,6) (2) nootropic properties; (7) and (3) antioxidant action. (8)
When procaine enters the body, it is broken down into para-aminobenzoic acid (PABA, a para B-vitamin), and diethylaminoethanol (DEAE), both of which are naturally present in the body (Fig. 2). Both of these substances are biologically active and have numerous beneficial effects of their own. Although the majority of the research involving Gerovital and Aslavital attribute the benefits to the procaine molecule, there is still controversy as to whether the effects are due to the procaine molecule itself, or to its breakdown products, PABA and DEAE. (9)
Anti-Aging Effects of PABA
PABA has been used as a component of many commercially available sunscreens due to its ability to block damaging ultraviolet rays. Skin damage due to sunlight causes or accelerates many of the characteristic skin changes that we attribute to aging. (10) PABA, both topically and orally, is truly an antiaging substance in terms of protecting
the skin from the sun.
PABA is a naturally occurring, water-soluble compound which is found in many foods as a cofactor of the vitamin B complex (associated with folate). It first became popular due to the writings of pioneer nutritionists like Gaylord Hauser, Lelord Kordell, and Adelle Davis. (11,12,13) Several decades later, life extension scientists Durk Pearson and Sandy Shaw extolled the potential virtues of PABA in their best-seller, Life Extension — A Practical Scientific Approach.
Is PABA a Vitamin?
By definition, a vitamin is a biologically active organic compound that is essential for an organisms normal health and growth, a deficiency of which results in a deficiency disease or disorder. Though PABA has many vitamin-like qualities, it fails to meet the strict definition of a vitamin. Early animal studies did, however, demonstrate that PABA increased lactation in rodents and increased the weight of chicks that were fed a diet with low levels of folate. These early studies suggested that PABA was essential, and it has erroneously been described as a B vitamin by many nutritionists and health educators in dozens of books. PABA is actually a structural part of folic acid. Although PABA is not technically a vitamin, it does appear to have a number of interesting and potentially valuable uses.
The Anti-Gray Hair Vitamin
One very interesting application for this versatile substance is its potential to restore hair to its natural color. In 1941, Dr. B. F. Sieve reported that administration of 200 mg of PABA per day for two months resulted in marked darkening of the hair in 30 patients with gray hair. (15) Brandaleone and colleagues (1944) reported that 2 of 33 individuals with grey hair had significant hair color change when administered 200 mg of PABA with 100 mg of calcium pantothenate (vitamin B5) and 50 grams (approx. 2 ounces) of brewers yeast for eight months. (16)
Dr. Chris Zarafonetis (1964) of Temple University followed these investigations with a report that described 5 cases of dramatic hair color change and hair regrowth in 20 patients with markedly gray hair, who were taking 6-24 grams of PABA per day for other conditions. (17) The hair color changes were serendipitous results of this therapy.Zarafonetis concluded that consumption of 6-24 grams of PABA per day for at least 6 weeks restored the natural hair color of 25% of people with markedly gray hair. He did not speculate on the mechanism for hair color restoration and pointed out that the effects were highly variable and might require extended periods of administration.
Zvak (1986) confirmed that forty years ago, large doses of PABA were clearly shown to darken grey hair; the regained color was lost within 3-4 weeks of stopping the treatment.(18) While it is clear that the hair color restoration effects of PABA were less than universal, any therapy which results in 10-25% reversal of an irreversible condition (like hair grayness) must certainly be considered significant.
PABA as an Antioxidant
It has been well established that PABA is a potent neutralizer of singlet molecular oxygen, a potent free radical which is a common by-product of normal metabolism. (19)
In theory, use of antioxidants protects cellular membranes and mitochondrial DNA from free radical attack. The mitochondria are the energy-producers of the cells. Mitochondrial degradation results in reduced cellular energy production which causes numerous undesirable physiological conditions, which may include fatigue and the aging process itself. As an antioxidant, PABA also provides protection against ozone, smoking, and other air pollutants that damage other cell structures and membranes through oxidative stress. PABA promotes cell membrane fluidity by preventing such oxidant damage.
PABA as an Anti-Crosslinking Agent
The crosslinkage theory of aging was proposed by Professor Johan Bjorksten in 1974. Bjorksten believed that the aging process was due to crosslinks (undesirable bonds induced by excess free radicals) which formed between molecules). Bjorksten theorized that these crosslinks progressively impaired the function of the body, the end
result of which was aging. (20) PABA appears to slow and in some cases even reverse crosslinking in the protein structures of connective tissues such as collagen.
Collagen crosslinking
— in addition to resulting in the loss of flexibility with age, and perhaps the aging process itself — also is the primary process in a number of fibrotic diseases, including: Peyronies disease (formation of fibrotic plaques of the penis, usually in men over 50, resulting in painful, crooked erections, rendering intercourse difficult or impossible); Dupuytrens contracture (wherein the flexor tendons of the fingers of the hands become fibrotic and contract, rendering the fingers useless); and scleroderma (a rare condition
characterized by heavily crosslinked skin and tissues, with disabling systemic results). Zarafonetis (1964) found PABA to have a marked therapeutic effect in these conditions, in doses of 12 grams per day. (21) Zarafonetis also used PABA to treat dermatitis herpetiformis (200 mg, 4-5 times daily), and vitiligo (a depigmenting disease). By slowing crosslinking, PABA may promote greater body flexibility in normally aging individuals.
Potential Side Effects and Cautions
High-dose PABA is generally well-tolerated, its most significant adverse side effects being diarrhea and nausea, which resolved with cessation of use, or lowering of the dose. As PABA is water soluble, it is rapidly excreted in the urine, and must therefore be administered in divided doses throughout the day. High-dose PABA should be discontinued when taking sulfa antibiotics (like Bactrim or Septra).
PABA Summary
Pearson and Shaw described PABA as an antioxidant which could: (1) slow crosslinking; (2) enhance flexibility; (3) promote membrane fluidity; (4) provide protection against ozone, secondhand smoke and other air pollutants; (5) alleviate the inflammation of arthritis; and (6) restore the original color of hair in perhaps 10-25% of cases. Pearson and Shaw reported they consumed as much as three grams of PABA per day. (14)
DMAE
Dimethylaminoethanol (DMAE) is a substance that is closely related to DEAE (Figure 3) — the other metabolic by-product of GH3. DMAE is a naturally occurring nutrient found in such brain foods as anchovies and sardines. It stimulates the production of choline, which in turn allows the brain to optimize production of acetylcholine (Fig. 4). Acetylcholine is the primary neurotransmitter involved in learning and memory.
DMAE is a mild cerebral stimulant, which was at one time approved by the FDA as being possibly effective for the following conditions:
Learning problems associated with underachieving and shortened attention span.
Behavior problems associated with hyperactivity.
Combined hyperkinetic behavior and learning disorders with underachieving, reading and speech difficulties, impaired motor coordination, and impulsive/compulsive behavior, often described as asocial, antisocial, or delinquent.
The learning problems mentioned above, although usually childhood disorders, are also not infrequently seen in adults. They are usually treated with much more potent and addictive amphetamines (like Ritalin). DMAE is a safe and non-addictive form of therapy for these conditions. DMAE produces a mild stimulant effect, which develops slowly over a period of several weeks. There is no drug-like letdown or depression if the substance is discontinued. (22)
DMAE for Adult and Childhood Learning Disorders
For those children and adults who suffer from ADD, ADHD, and other learning disorders (and even for those who dont) I recommend DMAE (dimethylaminoethanol). DMAE has been used for years to improve behavioral disorders in children, and may have positive effects on intelligence and grades as well.
In 1958, Dr. Leon Oettinger, Jr., found that DMAE:
Accelerated mental processes
Improved concentration span
Abolished early morning fogginess
Relieved lassitude and mild depression with obvious letdown when it was discontinued
Was useful in schizophrenia of long duration (with prolonged treatment)
Decreased irritability and reduced overactivity, leading to a much better overall social adaptation and improved scholastic functioning
Increased attention span
Did not cause drowsiness
Improved IQ!
Furthermore, he found that DMAE had numerous advantages over the amphetamines (like Ritalin) in that there were no effects on heart rate or blood pressure and no induced jitteriness. Instead of causing anorexia (loss of appetite) like the amphetamines, he found that DMAE actually improved appetite in many patients and caused no
interference with sleep. In fact, he found that DMAE actually reduced sleep requirements. Dr. Oettinger concluded that DMAE was a most useful tool in the handling of the child with behavioral problems.(23)
In 1960, Dr. Stanley Geller reported on a double-blind study of 75 children, that DMAE in doses of 50 mg twice daily resulted in improved functioning capacity, puzzle-solving
ability and organization of activity. (24)
In another double-blind study of fifty children who had been diagnosed as suffering from hyperkinetic syndrome, DMAE was administered in doses up to 500 mg/day (300 mg in the morning, another 200 mg at lunch). The author concluded that DMAE, when administered at doses of 300-500 mg per day for 12 weeks to moderately disturbed hyperkinetic children (six to 12 years of age) produces greater overall improvement in comparison to patients similarly treated with a placebo. 25)
DMAE for Chronic Fatigue, Depression, and to Enhance Dreaming
Kugel and Alexander reported that DMAE had also been demonstrated to be useful in the treatment of chronic fatigue and depression in children, (26) and Sergin reported the phenomena of DMAE-induced lucid dreaming, and speculated on its effects in normalizing brain function and mood. (27)
DMAE Improves Movement
Disorders and Prevents Adverse Effects of L-DOPA in Treatment of Parkinsonism
In 1974, Dr. Edith Miller added DMAE in doses ranging from 300-900 mg per day to the regimen of Parkinsons patients who had begun to exhibit adverse effects from high dosages of L-DOPA. DMAE administration resulted in a complete resolution of the L-DOPA-induced abnormal movements in a majority of the patients. Dr. Miller concluded that DMAE seems to be the first effective measure to combat L-DOPA-induced dyskinesias safely and effectively without interfering with the beneficial effects of L-DOPA
therapy. (28)
In a subsequent study, Dr. E. Daniel of the Portland VA Hospital used doses of DMAE ranging in dosages from 400 to 600 mg/day in a variety of patients with involuntary movement disorders, including benign essential tremor, tardive dyskinesia, and even blepharospasm (eyelid twitching). Use of DMAE resulted in improvement in all symptoms, with the exception of those suffering from Huntingtons chorea. (29)
DMAE Inhibits Formation of Aging Pigment
One of the most dramatic and well-documented effects of DMAE is its ability to inhibit the formation of aging pigment (lipofuscin). Lipofuscin is believed to be formed by the inefficient metabolism of fatty acids, and its accumulation in the cells is one of the most obvious and regularly reported cytological (cellular) changes with age. Lipofuscin
accumulates with age in all body tissues. Although no known adverse effects are known to result from lipofuscin accumulation, it certainly does no good, acting as intracellular garbage. Even if it is not harmful, lipofuscin is often cosmetically unacceptable, as it is the brownish pigment that causes liver spots on the backs of the hands of many people over 50 years of age.
DMAE not only can prevent the formation of lipofuscin, but it also actually flushes it from the body. Many people gauge the rate of lipofuscin removal from their hearts
and brains by watching their liver spots disappear with long-term supplementation of DMAE. It usually takes about six months for significant changes to take place — many spots resolving completely.
Life-Extending Effects of DMAE
Richard Hochschild, designer of the H-SCAN (probably the most well tested system designed to measure human biological age), evaluated the potential life-extending effect of DMAE on old mice. DMAE administration in the drinking water resulted in a reduction in mortality and an increase in both mean and maximum survival times (Fig. 5). (30)
Conclusion
In his book, Secrets of Life Extension, John Mann wrote that GH3 may not be the key to extraordinary life extension, but it appears to help, treat and delay the onset of many of the symptoms and side effects of aging. It can be a useful adjuvant to other longevity agents, and will, most likely, potentiate their effectiveness.(31) I agree with Johns assessment.
Gerovital and Aslavital are unapproved by the FDA, and are therefore largely unavailable in the US. Nevertheless, it is still possible for people who wish to avail themselves
of this therapy by asking their physicians to prescribe it for them through a compounding pharmacy. Although not approved for anti-aging use, physicians can legally prescribe drugs that are not approved in this country, but which are not specifically illegal.
An alternative is to use a PABA-DMAE complex containing the ingredients that Prof. Aslan found to work synergistically with her formula. DMAE and PABA in the proper concentrations may have effects as dramatic as those of GH3 itself, and may provide a variety of independent positive effects as well. Consequently, since DMAE and PABA are both readily available, inexpensive dietary supplements, this may be a satisfactory (and perhaps, a superior) alternative.
References
1. Aslan, A. Theoretical bases of procaine therapy (Gerovital H3 and Aslavital) in the prophylaxis of aging. Romanian Journal of Gerontology and Geriatrics, 1: 1, 5-15, 1980.
2. Stroescu, V. The experimental and clinical pharmacology of procaine, Gerovital H3 and Aslavital. Romanian Journal of Gerontology and Geriatrics, No.4, Volume 9, pp. 427-437. 1988.
3. Dean, W. Biological Aging Measurement -Pre-Requisite for effective human aging intervention. Romanian Journal of Gerontology and Geriatrics, Supplement to No. (1, Vol 9: 26. 1988.
4. MacFarlane, D. Procaine HCl (Gerovital H3): A weak, reversible, fully competitive inhibitor of monoamine oxidase. Fed Proc, 1975, 34: 1, 108
5. Hrachovec, J. Inhibitory effect of gerovital H3 on rat brain monoamine oxidase, Fed Proc, 1972, 31: 2, 604.
6. Aslan, A. Theoretical and practical aspects of chemotherapeutic techniques in the retardation of the aging process. Romanian Journal of Gerontology and Geriatrics, 1: 4, 3-11, 1983.
7. Stroescu, V., Constantinescu, I., Brezina, AI., Sotirescu, D., and Vrabiescu, AI. Experimental studies into the nootropic effects exerted upon the central nervous system by Aslavital versus procaine and Pyracetam. Romanian Journal of Gerontology and Geriatrics, No. 2, Volume 7, pp. 115-121, 1988.
8. Rusu, C., and Lupeanu, E. Inhibitory effect of Gerovital H3 and Aslavital on the production of the superoxide radical. Romanian Journal of Gerontology and Geriactrics, Supplement to No. (1, Volume 9, pp. 99-100, 1988.
9. Aslan, A., Turcu, E., Simion, N., Dobre, V., Strungaru, C., Stroica, E. Experimental Researches regarding the pharmacodynamic characteristics of procaine hydrolysis pro- ducts- DEAE and PABA. Romanian Journal of Gerontology and Geriatrics, Supplement to No. (1. Vol 9, 101-102, 1988.
10. Gilchrest, B.A. Skin and Aging Processes. CRC Press. Boca Raton, 1984.
11. Hauser, G. Look Younger, Live Longer, Crest Books, New York, 1962.
12. Kordel, L. Eat and Grow Younger, MacFadden Books, 1962.
13. Davis, A. Lets Eat Right to Keep Fit. Harcourt, Brace Jovanovich, New York, 1970.
14. Pearson, D., and Shaw, S. Life Extension A Practical, Scientific Approach, 1982, Warner Books, New York.
15. Sieve, B.F. Clinical achromotrichia. Science, 1941, 94: 257.
16. Brandaleone, H., Maine, E., and Steele, J.M. The effect of calcium pantothenate and para-aminobenzoic acid on gray hair in man. Am J Medical Science, 1944, 206: 315.
17. Zarafonetis, C. Darkening of gray hair during para-amino-benzoic acid therapy. J Investigative Dermatology, 399-401.
18. Zvak, C. The Science of Hair Care, 1986, Marcel Dekker, Inc., New York.
19. Allen, J.M. Rapid Reaction of Singlet Molecular Oxygen with P -Aminobenzoic Acid (PABA) in Aqueous Solution. Biochemical and Biophysical Research Communications, July, 1995.
20. Bjorksten, J. Crosslinkage and the aging process, in: Theoretical Aspects of Aging, by Morris Rockstein (ed), Academic Press, NY, 1974.
21. Zarafonetis, C. Antifibrotic Therapy with POTABA. American Journal of Medical Sciences, 1964, 248:550-561.
22. Pfeiffer, G.C. Parasympathetic Neurohormones. Possible precursors and effect on behavior. Int. Review of Neurobiology, pp. 195-244, 1959.
23. Oettinger, L. The use of Deanol in the treatment of disorders of behavior in children. J. Pediat, 1958, 53: 761-675.
24. Geller, S. J. Comparison of a tranquilizer and a psychic energizer. JAMA, 1960, 174: 89-92.
25. Coleman, N., Dexheimer, P., Dimascio, A., Redman, W., and Finnerty, R. Deanol in the treatment of hyperkinetic children. Psychosomatics, 1976, 17: 68-72.
26. Kugel, R. B., and Alexander, T. The effect of a central nervous system stimulant (Deanol) on behavior. Pediatrics. 1963, 31: 651-655.
27. Sergin, W. Use of DMAE in the induction of lucid dreams. Med Hypotheses, 1988, 26: 4, 255-257.
28. Miller, E. Deanol (DMAE) in the treatment of levodopa-induced dyskinesias. Neurology, February, 1974, 116-119.
29. Daniel, E. Mood alterations during deanol therapy. Psychopharmacology, 62: 2, 187-191, 1979.
30. Hochschild, R. Effect of dimethylaminoethanol on the life span of senile male A/J mice. Exp Gerontol, 1973, 8: 4, 185-191.
31. Mann, John. Secrets of Life Extension, Bantam Books, New York, 1982
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DMAE and PABA
An Alternative to Gerovital (GH3), the Romanian Youth Drug
By Ward Dean, MD
In Romania, Gerovital, or GH3, has been used for over 50 years to help people look and feel younger. It has attracted thousands of people each year to the spas of Romania and Western Europe where this therapy has been widely used. GH3 is a modification of the local anesthetic, procaine. It was developed for anti-aging uses by Professor Ana Aslan in Romania in the 1940s (Fig. 1). The discovery of procaines potential anti-aging properties was a serendipitous finding. Prof. Aslan was experimenting with the pain-relieving effects of procaine on patients with severe arthritis by injecting it into the arteries (!) which supplied blood to the area of the affected joints. She logically theorized that procaine, being an anesthetic, would relieve the joint pain. She was surprised to find that in addition to dramatic relief of joint pains, many patients also noted (1) improved memory, (2) less depression, (3) more energy, (4) restoration of normal hair color, (5) improved skin tone, and (6) a generalized feeling of well-being. (1)
These provocative results encouraged Prof. Aslan to carry out additional studies to test the effects of procaine on thousands of people. She did this at the Romanian National Institute of Gerontology and Geriatrics which she founded in 1950 — the first government-sponsored aging research institute in the world. Aslan found that by adding benzoic acid as a preservative, and potassium metabisulfite as an antioxidant, the procaine molecule was stabilized, and the effects were even more dramatic than with procaine alone. She called her improved form of procaine Gerovital, or GH3. She later added pyridoxine (vitamin B6), mesoinositol, and glutamic acid to this formula, to form yet another version called Aslavital. Aslavital was reported to have even more powerful and beneficial effects on memory, atherosclerosis, and other degenerative conditions than the original Gerovital H3. (2)
Gerovital
H3 is approved by the Romanian equivalent of the FDA for use in the treatment of numerous diseases, including: (1) prevention and treatment of the aging process; (2) depression; (3) arthritis; (4) asthma; (5) gastric and duodenal ulcers, (6) osteoporosis, and many other conditions.
In 1987, I traveled to Romania to attend and present a paper at the Romanian National Congress of Gerontology and Geriatrics (Dean). (3) I was interested in learning more
about Gerovital and Aslavital — to see first-hand how it was administered, meet patients undergoing the therapy, and review the scientific studies that had been performed. I was impressed by the body of scientific research that supported the use of procaine, Gerovital H3, and Aslavital as prophylactic and therapeutic agents against the aging process.
How Does Gerovital Work?
Procaine, as Gerovital H3 and Aslavital, has numerous documented mechanisms of action. These include (1) inhibition of monoamine oxidase (an enzyme in the brain which increases with age); (4,5,6) (2) nootropic properties; (7) and (3) antioxidant action. (8)
When procaine enters the body, it is broken down into para-aminobenzoic acid (PABA, a para B-vitamin), and diethylaminoethanol (DEAE), both of which are naturally present in the body (Fig. 2). Both of these substances are biologically active and have numerous beneficial effects of their own. Although the majority of the research involving Gerovital and Aslavital attribute the benefits to the procaine molecule, there is still controversy as to whether the effects are due to the procaine molecule itself, or to its breakdown products, PABA and DEAE. (9)
Anti-Aging Effects of PABA
PABA has been used as a component of many commercially available sunscreens due to its ability to block damaging ultraviolet rays. Skin damage due to sunlight causes or accelerates many of the characteristic skin changes that we attribute to aging. (10) PABA, both topically and orally, is truly an antiaging substance in terms of protecting
the skin from the sun.
PABA is a naturally occurring, water-soluble compound which is found in many foods as a cofactor of the vitamin B complex (associated with folate). It first became popular due to the writings of pioneer nutritionists like Gaylord Hauser, Lelord Kordell, and Adelle Davis. (11,12,13) Several decades later, life extension scientists Durk Pearson and Sandy Shaw extolled the potential virtues of PABA in their best-seller, Life Extension — A Practical Scientific Approach.
Is PABA a Vitamin?
By definition, a vitamin is a biologically active organic compound that is essential for an organisms normal health and growth, a deficiency of which results in a deficiency disease or disorder. Though PABA has many vitamin-like qualities, it fails to meet the strict definition of a vitamin. Early animal studies did, however, demonstrate that PABA increased lactation in rodents and increased the weight of chicks that were fed a diet with low levels of folate. These early studies suggested that PABA was essential, and it has erroneously been described as a B vitamin by many nutritionists and health educators in dozens of books. PABA is actually a structural part of folic acid. Although PABA is not technically a vitamin, it does appear to have a number of interesting and potentially valuable uses.
The Anti-Gray Hair Vitamin
One very interesting application for this versatile substance is its potential to restore hair to its natural color. In 1941, Dr. B. F. Sieve reported that administration of 200 mg of PABA per day for two months resulted in marked darkening of the hair in 30 patients with gray hair. (15) Brandaleone and colleagues (1944) reported that 2 of 33 individuals with grey hair had significant hair color change when administered 200 mg of PABA with 100 mg of calcium pantothenate (vitamin B5) and 50 grams (approx. 2 ounces) of brewers yeast for eight months. (16)
Dr. Chris Zarafonetis (1964) of Temple University followed these investigations with a report that described 5 cases of dramatic hair color change and hair regrowth in 20 patients with markedly gray hair, who were taking 6-24 grams of PABA per day for other conditions. (17) The hair color changes were serendipitous results of this therapy.Zarafonetis concluded that consumption of 6-24 grams of PABA per day for at least 6 weeks restored the natural hair color of 25% of people with markedly gray hair. He did not speculate on the mechanism for hair color restoration and pointed out that the effects were highly variable and might require extended periods of administration.
Zvak (1986) confirmed that forty years ago, large doses of PABA were clearly shown to darken grey hair; the regained color was lost within 3-4 weeks of stopping the treatment.(18) While it is clear that the hair color restoration effects of PABA were less than universal, any therapy which results in 10-25% reversal of an irreversible condition (like hair grayness) must certainly be considered significant.
PABA as an Antioxidant
It has been well established that PABA is a potent neutralizer of singlet molecular oxygen, a potent free radical which is a common by-product of normal metabolism. (19)
In theory, use of antioxidants protects cellular membranes and mitochondrial DNA from free radical attack. The mitochondria are the energy-producers of the cells. Mitochondrial degradation results in reduced cellular energy production which causes numerous undesirable physiological conditions, which may include fatigue and the aging process itself. As an antioxidant, PABA also provides protection against ozone, smoking, and other air pollutants that damage other cell structures and membranes through oxidative stress. PABA promotes cell membrane fluidity by preventing such oxidant damage.
PABA as an Anti-Crosslinking Agent
The crosslinkage theory of aging was proposed by Professor Johan Bjorksten in 1974. Bjorksten believed that the aging process was due to crosslinks (undesirable bonds induced by excess free radicals) which formed between molecules). Bjorksten theorized that these crosslinks progressively impaired the function of the body, the end
result of which was aging. (20) PABA appears to slow and in some cases even reverse crosslinking in the protein structures of connective tissues such as collagen.
Collagen crosslinking
— in addition to resulting in the loss of flexibility with age, and perhaps the aging process itself — also is the primary process in a number of fibrotic diseases, including: Peyronies disease (formation of fibrotic plaques of the penis, usually in men over 50, resulting in painful, crooked erections, rendering intercourse difficult or impossible); Dupuytrens contracture (wherein the flexor tendons of the fingers of the hands become fibrotic and contract, rendering the fingers useless); and scleroderma (a rare condition
characterized by heavily crosslinked skin and tissues, with disabling systemic results). Zarafonetis (1964) found PABA to have a marked therapeutic effect in these conditions, in doses of 12 grams per day. (21) Zarafonetis also used PABA to treat dermatitis herpetiformis (200 mg, 4-5 times daily), and vitiligo (a depigmenting disease). By slowing crosslinking, PABA may promote greater body flexibility in normally aging individuals.
Potential Side Effects and Cautions
High-dose PABA is generally well-tolerated, its most significant adverse side effects being diarrhea and nausea, which resolved with cessation of use, or lowering of the dose. As PABA is water soluble, it is rapidly excreted in the urine, and must therefore be administered in divided doses throughout the day. High-dose PABA should be discontinued when taking sulfa antibiotics (like Bactrim or Septra).
PABA Summary
Pearson and Shaw described PABA as an antioxidant which could: (1) slow crosslinking; (2) enhance flexibility; (3) promote membrane fluidity; (4) provide protection against ozone, secondhand smoke and other air pollutants; (5) alleviate the inflammation of arthritis; and (6) restore the original color of hair in perhaps 10-25% of cases. Pearson and Shaw reported they consumed as much as three grams of PABA per day. (14)
DMAE
Dimethylaminoethanol (DMAE) is a substance that is closely related to DEAE (Figure 3) — the other metabolic by-product of GH3. DMAE is a naturally occurring nutrient found in such brain foods as anchovies and sardines. It stimulates the production of choline, which in turn allows the brain to optimize production of acetylcholine (Fig. 4). Acetylcholine is the primary neurotransmitter involved in learning and memory.
DMAE is a mild cerebral stimulant, which was at one time approved by the FDA as being possibly effective for the following conditions:
Learning problems associated with underachieving and shortened attention span.
Behavior problems associated with hyperactivity.
Combined hyperkinetic behavior and learning disorders with underachieving, reading and speech difficulties, impaired motor coordination, and impulsive/compulsive behavior, often described as asocial, antisocial, or delinquent.
The learning problems mentioned above, although usually childhood disorders, are also not infrequently seen in adults. They are usually treated with much more potent and addictive amphetamines (like Ritalin). DMAE is a safe and non-addictive form of therapy for these conditions. DMAE produces a mild stimulant effect, which develops slowly over a period of several weeks. There is no drug-like letdown or depression if the substance is discontinued. (22)
DMAE for Adult and Childhood Learning Disorders
For those children and adults who suffer from ADD, ADHD, and other learning disorders (and even for those who dont) I recommend DMAE (dimethylaminoethanol). DMAE has been used for years to improve behavioral disorders in children, and may have positive effects on intelligence and grades as well.
In 1958, Dr. Leon Oettinger, Jr., found that DMAE:
Accelerated mental processes
Improved concentration span
Abolished early morning fogginess
Relieved lassitude and mild depression with obvious letdown when it was discontinued
Was useful in schizophrenia of long duration (with prolonged treatment)
Decreased irritability and reduced overactivity, leading to a much better overall social adaptation and improved scholastic functioning
Increased attention span
Did not cause drowsiness
Improved IQ!
Furthermore, he found that DMAE had numerous advantages over the amphetamines (like Ritalin) in that there were no effects on heart rate or blood pressure and no induced jitteriness. Instead of causing anorexia (loss of appetite) like the amphetamines, he found that DMAE actually improved appetite in many patients and caused no
interference with sleep. In fact, he found that DMAE actually reduced sleep requirements. Dr. Oettinger concluded that DMAE was a most useful tool in the handling of the child with behavioral problems.(23)
In 1960, Dr. Stanley Geller reported on a double-blind study of 75 children, that DMAE in doses of 50 mg twice daily resulted in improved functioning capacity, puzzle-solving
ability and organization of activity. (24)
In another double-blind study of fifty children who had been diagnosed as suffering from hyperkinetic syndrome, DMAE was administered in doses up to 500 mg/day (300 mg in the morning, another 200 mg at lunch). The author concluded that DMAE, when administered at doses of 300-500 mg per day for 12 weeks to moderately disturbed hyperkinetic children (six to 12 years of age) produces greater overall improvement in comparison to patients similarly treated with a placebo. 25)
DMAE for Chronic Fatigue, Depression, and to Enhance Dreaming
Kugel and Alexander reported that DMAE had also been demonstrated to be useful in the treatment of chronic fatigue and depression in children, (26) and Sergin reported the phenomena of DMAE-induced lucid dreaming, and speculated on its effects in normalizing brain function and mood. (27)
DMAE Improves Movement
Disorders and Prevents Adverse Effects of L-DOPA in Treatment of Parkinsonism
In 1974, Dr. Edith Miller added DMAE in doses ranging from 300-900 mg per day to the regimen of Parkinsons patients who had begun to exhibit adverse effects from high dosages of L-DOPA. DMAE administration resulted in a complete resolution of the L-DOPA-induced abnormal movements in a majority of the patients. Dr. Miller concluded that DMAE seems to be the first effective measure to combat L-DOPA-induced dyskinesias safely and effectively without interfering with the beneficial effects of L-DOPA
therapy. (28)
In a subsequent study, Dr. E. Daniel of the Portland VA Hospital used doses of DMAE ranging in dosages from 400 to 600 mg/day in a variety of patients with involuntary movement disorders, including benign essential tremor, tardive dyskinesia, and even blepharospasm (eyelid twitching). Use of DMAE resulted in improvement in all symptoms, with the exception of those suffering from Huntingtons chorea. (29)
DMAE Inhibits Formation of Aging Pigment
One of the most dramatic and well-documented effects of DMAE is its ability to inhibit the formation of aging pigment (lipofuscin). Lipofuscin is believed to be formed by the inefficient metabolism of fatty acids, and its accumulation in the cells is one of the most obvious and regularly reported cytological (cellular) changes with age. Lipofuscin
accumulates with age in all body tissues. Although no known adverse effects are known to result from lipofuscin accumulation, it certainly does no good, acting as intracellular garbage. Even if it is not harmful, lipofuscin is often cosmetically unacceptable, as it is the brownish pigment that causes liver spots on the backs of the hands of many people over 50 years of age.
DMAE not only can prevent the formation of lipofuscin, but it also actually flushes it from the body. Many people gauge the rate of lipofuscin removal from their hearts
and brains by watching their liver spots disappear with long-term supplementation of DMAE. It usually takes about six months for significant changes to take place — many spots resolving completely.
Life-Extending Effects of DMAE
Richard Hochschild, designer of the H-SCAN (probably the most well tested system designed to measure human biological age), evaluated the potential life-extending effect of DMAE on old mice. DMAE administration in the drinking water resulted in a reduction in mortality and an increase in both mean and maximum survival times (Fig. 5). (30)
Conclusion
In his book, Secrets of Life Extension, John Mann wrote that GH3 may not be the key to extraordinary life extension, but it appears to help, treat and delay the onset of many of the symptoms and side effects of aging. It can be a useful adjuvant to other longevity agents, and will, most likely, potentiate their effectiveness.(31) I agree with Johns assessment.
Gerovital and Aslavital are unapproved by the FDA, and are therefore largely unavailable in the US. Nevertheless, it is still possible for people who wish to avail themselves
of this therapy by asking their physicians to prescribe it for them through a compounding pharmacy. Although not approved for anti-aging use, physicians can legally prescribe drugs that are not approved in this country, but which are not specifically illegal.
An alternative is to use a PABA-DMAE complex containing the ingredients that Prof. Aslan found to work synergistically with her formula. DMAE and PABA in the proper concentrations may have effects as dramatic as those of GH3 itself, and may provide a variety of independent positive effects as well. Consequently, since DMAE and PABA are both readily available, inexpensive dietary supplements, this may be a satisfactory (and perhaps, a superior) alternative.
References
1. Aslan, A. Theoretical bases of procaine therapy (Gerovital H3 and Aslavital) in the prophylaxis of aging. Romanian Journal of Gerontology and Geriatrics, 1: 1, 5-15, 1980.
2. Stroescu, V. The experimental and clinical pharmacology of procaine, Gerovital H3 and Aslavital. Romanian Journal of Gerontology and Geriatrics, No.4, Volume 9, pp. 427-437. 1988.
3. Dean, W. Biological Aging Measurement -Pre-Requisite for effective human aging intervention. Romanian Journal of Gerontology and Geriatrics, Supplement to No. (1, Vol 9: 26. 1988.
4. MacFarlane, D. Procaine HCl (Gerovital H3): A weak, reversible, fully competitive inhibitor of monoamine oxidase. Fed Proc, 1975, 34: 1, 108
5. Hrachovec, J. Inhibitory effect of gerovital H3 on rat brain monoamine oxidase, Fed Proc, 1972, 31: 2, 604.
6. Aslan, A. Theoretical and practical aspects of chemotherapeutic techniques in the retardation of the aging process. Romanian Journal of Gerontology and Geriatrics, 1: 4, 3-11, 1983.
7. Stroescu, V., Constantinescu, I., Brezina, AI., Sotirescu, D., and Vrabiescu, AI. Experimental studies into the nootropic effects exerted upon the central nervous system by Aslavital versus procaine and Pyracetam. Romanian Journal of Gerontology and Geriatrics, No. 2, Volume 7, pp. 115-121, 1988.
8. Rusu, C., and Lupeanu, E. Inhibitory effect of Gerovital H3 and Aslavital on the production of the superoxide radical. Romanian Journal of Gerontology and Geriactrics, Supplement to No. (1, Volume 9, pp. 99-100, 1988.
9. Aslan, A., Turcu, E., Simion, N., Dobre, V., Strungaru, C., Stroica, E. Experimental Researches regarding the pharmacodynamic characteristics of procaine hydrolysis pro- ducts- DEAE and PABA. Romanian Journal of Gerontology and Geriatrics, Supplement to No. (1. Vol 9, 101-102, 1988.
10. Gilchrest, B.A. Skin and Aging Processes. CRC Press. Boca Raton, 1984.
11. Hauser, G. Look Younger, Live Longer, Crest Books, New York, 1962.
12. Kordel, L. Eat and Grow Younger, MacFadden Books, 1962.
13. Davis, A. Lets Eat Right to Keep Fit. Harcourt, Brace Jovanovich, New York, 1970.
14. Pearson, D., and Shaw, S. Life Extension A Practical, Scientific Approach, 1982, Warner Books, New York.
15. Sieve, B.F. Clinical achromotrichia. Science, 1941, 94: 257.
16. Brandaleone, H., Maine, E., and Steele, J.M. The effect of calcium pantothenate and para-aminobenzoic acid on gray hair in man. Am J Medical Science, 1944, 206: 315.
17. Zarafonetis, C. Darkening of gray hair during para-amino-benzoic acid therapy. J Investigative Dermatology, 399-401.
18. Zvak, C. The Science of Hair Care, 1986, Marcel Dekker, Inc., New York.
19. Allen, J.M. Rapid Reaction of Singlet Molecular Oxygen with P -Aminobenzoic Acid (PABA) in Aqueous Solution. Biochemical and Biophysical Research Communications, July, 1995.
20. Bjorksten, J. Crosslinkage and the aging process, in: Theoretical Aspects of Aging, by Morris Rockstein (ed), Academic Press, NY, 1974.
21. Zarafonetis, C. Antifibrotic Therapy with POTABA. American Journal of Medical Sciences, 1964, 248:550-561.
22. Pfeiffer, G.C. Parasympathetic Neurohormones. Possible precursors and effect on behavior. Int. Review of Neurobiology, pp. 195-244, 1959.
23. Oettinger, L. The use of Deanol in the treatment of disorders of behavior in children. J. Pediat, 1958, 53: 761-675.
24. Geller, S. J. Comparison of a tranquilizer and a psychic energizer. JAMA, 1960, 174: 89-92.
25. Coleman, N., Dexheimer, P., Dimascio, A., Redman, W., and Finnerty, R. Deanol in the treatment of hyperkinetic children. Psychosomatics, 1976, 17: 68-72.
26. Kugel, R. B., and Alexander, T. The effect of a central nervous system stimulant (Deanol) on behavior. Pediatrics. 1963, 31: 651-655.
27. Sergin, W. Use of DMAE in the induction of lucid dreams. Med Hypotheses, 1988, 26: 4, 255-257.
28. Miller, E. Deanol (DMAE) in the treatment of levodopa-induced dyskinesias. Neurology, February, 1974, 116-119.
29. Daniel, E. Mood alterations during deanol therapy. Psychopharmacology, 62: 2, 187-191, 1979.
30. Hochschild, R. Effect of dimethylaminoethanol on the life span of senile male A/J mice. Exp Gerontol, 1973, 8: 4, 185-191.
31. Mann, John. Secrets of Life Extension, Bantam Books, New York, 1982
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Friday, November 23, 2007
EMMANA WHO I KNOW WHO DANNY AND LEE SAVED
http://www.youtube.com/watch?v=ybXLVNo_7wM http://www.youtube.com/watch?v=zSStObcSVbQ&feature=related http://www.myspace.com/emmana1 I WAS BLOWN AWAY WHEN I SAW HER AGE REVERSED
Thursday, September 6, 2007
EDTA ORAL CHELATION
EDTA 625 MG FAST ABSORBING EDTA DISODIUM CHELATE
Sublingual B12 Discount Vitamins and more.
Thursday, September 6, 2007; Wonderlabs, Nashville Tennessee. . Home | Company | Shipping | Customer Service | How To Shop | Contact Us
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Select Category0 Empty Capsules00 Empty CapsulesA & D VitaminsAcneAllergy & Hayfever AntihistamineAloe VeraAmino AcidsAnimal NutritionalsAntacidAntioxidantsAnxiety, Stress, TensionB-ComplexBaby ProductsBack HealthBack, Neck & Body SupportsBee ProductsBlood Glucose ControlBone SupportCalcium/Bone SupportCapsules, EmptyCapsules, Empty VegetableCelestial SeasoningsChildrens ProductsCholesterol SolutionsChromium ProductsCinnamonCoenzyme Q10Cold Sore RemediesCold, Cough, FluColon CareColostrumCough DropsCough SyrupDental CareDiabetic AidsDiarrheaDigestive SupportEar & HearingEDTAEmpty BottlesEmpty Gelatin CapsulesEmpty Vegetable CapsulesEnergyEquine ProductsEssential OilsEster C Vitamin CEye CareFish OilFoot CareGarlicGas ReliefGinsengGland ProductsGlucosamine/Chondroitin/MSMGreen FoodsGreen TeaHair, Skin & NailsHeart HealthHemorrhoidal HealthHemp ProductsHerbsHomeopathicHormone SupportIbuprofenImmune System SupportIron SupplementJoint HealthJoint Health Top ProductsLaxativesLecithinLeg CrampsLiquid VitaminsLiver HealthLung HealthMemory & Brain HealthMen's ProductsMenopausal SupportMineralsMulti-Vitamin PacksMulti-VitaminsMuscle Cramps, Tension & StressMushroom ProductsNail CareNasal SprayNat. Brand, American BioscienceNat. Brand, American HealthNat. Brand, Body RescueNat. Brand, Food ScienceNat. Brand, HomeocareNat. Brand, HylandsNat. Brand, JasonNat. Brand, Lane LabsNat. Brand, Maitake ProductsNat. Brand, NaturalCareNat. Brand, Nutrition NowNat. Brand, RidgecrestNat. Brand, Sonne'sNat. Brand, UAS LabsNauseaNew ProductsNutrition BarsOmega-3 Fatty AcidsPain ReliefPersonal Care ProductsPersonal HygienePet CarePowders & GranulesProbioticsProteinSexual EnhancementShampoos and ConditionersSinus RemediesSkin CareSkin Care Vitamin E CreamSleep & TravelSoy SupplementsSpeciality ProductsSpecialsSports NutritionSteviaSunscreen/Sunburn ProductsSuppositoriesThroat, SoreThyroid HealthU.S. Animal NutritionalsUrinary HealthVitamin-BVitamin-CVitamin-EWeight ManagementWomen's Products
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Cod Liver Oil
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EDTA
Empty Capsules
Glucosamine
Chondroitin
Ibuprofen
Laxatives
Leg Cramps
Milk Thistle
MSM
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Muscle Spasms
Omega 3
Sinus Drainage
Sleep Aid
Stool Softener
Sublingual B-12
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Before engaging in
an online transaction,
look for the Better
Business Bureau (BBB)
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Rebuttal to CBS News Series about Dietary Supplements
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call within 30 days of the shipment date
to receive a full refund on that item.
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FREE Sample Shipped with Every Order.
Deal of the Day
RED CLOVER EXTRACT
Sale Price: $4.83
EDTA 625 MG
FAST ABSORBING
EDTA DISODIUM CHELATE
250 Capsules
Retail price: 32.99
Discount: 60%
Your price: 13.19
Quantity:
ORAL EDTA 625mg CAPSULES
Wonderlabs EDTA
There are several forms of EDTA on the market. Wonderlabs' EDTA is an amino acid (Ethylenediaminetetracetic acid disodium) which we refer to as EDTA disodium chelate. This is a special form of EDTA that is only produced by Wonderlabs. The advantage of Wonderlabs' form of EDTA is that it is the most acid resistant of all the other forms. It passes through the stomach without being destroyed by the stomach acid, thus it is the best absorbed of all the other EDTAs.
Depending on your general health, Wonderlabs' Oral EDTA absorption rate may be as high as 80%, allowing a smaller dose.
The purity of Wonderlabs' EDTA meets the requirements of the Food Codex, United States Pharmacopeia and European Pharmacopeoia.
There is no better form of EDTA than Wonderlabs' Oral EDTA disodium chelate form. It is far superior to other forms of EDTA.
--------------------------------------------------------------------------------
EDTA Frequently Asked Questions
Like "Should I take calcium with EDTA?" (Click Here)
--------------------------------------------------------------------------------
Customer Testimonials Sent To Wonderlabs (click here)
Supplement Facts
Serving Size 1 Capsule
Amount Per Serving
EDTA
(as Ethylenediaminetetraacetic Acid) 625 mg *
*Daily Value not established
Other ingredients: Gelatin, vegetable cellulose, vegetable magnesium sterate, silica.
Soy Free
DIRECTIONS: As a dietary supplement, take one (1) capsule two times daily preferably with a meal, (It can be taken before, during or after a meal).
CAUTION: If you are pregnant or nursing, consult your physician before taking this product.
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
Manufactured in an FDA Registered Facility using Good Manufacturing Practices (GMPs)
--------------------------------------------------------------------------------
Why Are Wonderlabs' Prices So Low Compared To Other Companies?
Over 40 years in the nutritional business. We manufacture in our own state-of-the-art FDA Registered Facility using Good Manufacturing Practices (GMPs) assuring correct potencies, freshness, quality and purity. We manufacture, package and ship from the same facility. We do no national advertising or multi-level marketing. From Wonderlabs to you for the lowest cost supplements on the net!
Click Here to see WONDERLABS' HEAVY METAL TESTING KIT.
Test your drinking water, saliva, urine, dust, paint and food.
All Available Sizes of this Item
Size Item No. Retail Discount Your Price
120 Capsules 9761 17.49 60% 6.99
250 Capsules 9762 32.99 60% 13.19
--------------------------------------------------------------------------------
Customers who purchased this item also purchased:
Co-Enzyme Q10
30 MG
Q10 ULTRA
Q10 30 mg. Energy for the Cells.
Your Price: $10.79
More Info
SUBLINGUAL B12
Vitamin B-12,
B6, Folic Acid and Biotin
Vegetarian Formula
Natural Cherry Flavored, 250 Sublingual Tablets
Your Price: $18.50
More Info
Category: Heart Health
--------------------------------------------------------------------------------
Click For More Information
--------------------------------------------------------------------------------
Top Categories
Allergy & Hayfever Antihistamine Anxiety Stress Tension Bone Support EDTA Chelation
Children's Products Diabetic Aids Fish Oil Omega 3's Glucosamine/Chondroitin/MSM
Leg Cramps Liver Health Men's Products Multi-Vitamins
Muscle Cramps, Tension & Stress Skin Care Sports Nutrition Vitamin-B
Vitamin-C Vitamin-E Weight Management Women's Products
--------------------------------------------------------------------------------
View All Categories
--------------------------------------------------------------------------------
Home | Company | Shipping | Customer Service | How To Shop | Contact Wonderlabs
®1996 - 2006 Wonder Laboratories. All rights reserved. 1.800.992.1672
Contact: Contact Wonderlabs
Sublingual B12 Discount Vitamins and more.
Thursday, September 6, 2007; Wonderlabs, Nashville Tennessee. . Home | Company | Shipping | Customer Service | How To Shop | Contact Us
Express Ordering
HackerSafe Information
Select Category0 Empty Capsules00 Empty CapsulesA & D VitaminsAcneAllergy & Hayfever AntihistamineAloe VeraAmino AcidsAnimal NutritionalsAntacidAntioxidantsAnxiety, Stress, TensionB-ComplexBaby ProductsBack HealthBack, Neck & Body SupportsBee ProductsBlood Glucose ControlBone SupportCalcium/Bone SupportCapsules, EmptyCapsules, Empty VegetableCelestial SeasoningsChildrens ProductsCholesterol SolutionsChromium ProductsCinnamonCoenzyme Q10Cold Sore RemediesCold, Cough, FluColon CareColostrumCough DropsCough SyrupDental CareDiabetic AidsDiarrheaDigestive SupportEar & HearingEDTAEmpty BottlesEmpty Gelatin CapsulesEmpty Vegetable CapsulesEnergyEquine ProductsEssential OilsEster C Vitamin CEye CareFish OilFoot CareGarlicGas ReliefGinsengGland ProductsGlucosamine/Chondroitin/MSMGreen FoodsGreen TeaHair, Skin & NailsHeart HealthHemorrhoidal HealthHemp ProductsHerbsHomeopathicHormone SupportIbuprofenImmune System SupportIron SupplementJoint HealthJoint Health Top ProductsLaxativesLecithinLeg CrampsLiquid VitaminsLiver HealthLung HealthMemory & Brain HealthMen's ProductsMenopausal SupportMineralsMulti-Vitamin PacksMulti-VitaminsMuscle Cramps, Tension & StressMushroom ProductsNail CareNasal SprayNat. Brand, American BioscienceNat. Brand, American HealthNat. Brand, Body RescueNat. Brand, Food ScienceNat. Brand, HomeocareNat. Brand, HylandsNat. Brand, JasonNat. Brand, Lane LabsNat. Brand, Maitake ProductsNat. Brand, NaturalCareNat. Brand, Nutrition NowNat. Brand, RidgecrestNat. Brand, Sonne'sNat. Brand, UAS LabsNauseaNew ProductsNutrition BarsOmega-3 Fatty AcidsPain ReliefPersonal Care ProductsPersonal HygienePet CarePowders & GranulesProbioticsProteinSexual EnhancementShampoos and ConditionersSinus RemediesSkin CareSkin Care Vitamin E CreamSleep & TravelSoy SupplementsSpeciality ProductsSpecialsSports NutritionSteviaSunscreen/Sunburn ProductsSuppositoriesThroat, SoreThyroid HealthU.S. Animal NutritionalsUrinary HealthVitamin-BVitamin-CVitamin-EWeight ManagementWomen's Products
View All Categories
Site Map
Add Wonderlabs.com to your Favorites
Free Stuff
Free Valerin Sample
Receive Our Free
News Letter
Order Our Catalog
Download Our Printable
Order Page
Links
Customer Service
Shipping Information
How To Shop
Contact Information
Affiliate Program
Home
Popular Products
Sublingual B12
Acetaminophen
Allergy Relief
Antacids
Antioxidant
Cinnamon
Cod Liver Oil
CoEnzyme-Q10
Coral Calcium
EDTA
Empty Capsules
Glucosamine
Chondroitin
Ibuprofen
Laxatives
Leg Cramps
Milk Thistle
MSM
MultiVitamin
Muscle Cramps
Muscle Spasms
Omega 3
Sinus Drainage
Sleep Aid
Stool Softener
Sublingual B-12
Vitamin B-12
Safe Shopping Site
Before engaging in
an online transaction,
look for the Better
Business Bureau (BBB)
OnLine Reliability seal.
Rebuttal to CBS News Series about Dietary Supplements
What will Your Shipping Cost?
100% Satisfaction Guarantee!
If you are dissatisfied with any product,
call within 30 days of the shipment date
to receive a full refund on that item.
FREE Valerin Sample.
Our Trademarked, All Natural Relaxant.
FREE Sample Shipped with Every Order.
Deal of the Day
RED CLOVER EXTRACT
Sale Price: $4.83
EDTA 625 MG
FAST ABSORBING
EDTA DISODIUM CHELATE
250 Capsules
Retail price: 32.99
Discount: 60%
Your price: 13.19
Quantity:
ORAL EDTA 625mg CAPSULES
Wonderlabs EDTA
There are several forms of EDTA on the market. Wonderlabs' EDTA is an amino acid (Ethylenediaminetetracetic acid disodium) which we refer to as EDTA disodium chelate. This is a special form of EDTA that is only produced by Wonderlabs. The advantage of Wonderlabs' form of EDTA is that it is the most acid resistant of all the other forms. It passes through the stomach without being destroyed by the stomach acid, thus it is the best absorbed of all the other EDTAs.
Depending on your general health, Wonderlabs' Oral EDTA absorption rate may be as high as 80%, allowing a smaller dose.
The purity of Wonderlabs' EDTA meets the requirements of the Food Codex, United States Pharmacopeia and European Pharmacopeoia.
There is no better form of EDTA than Wonderlabs' Oral EDTA disodium chelate form. It is far superior to other forms of EDTA.
--------------------------------------------------------------------------------
EDTA Frequently Asked Questions
Like "Should I take calcium with EDTA?" (Click Here)
--------------------------------------------------------------------------------
Customer Testimonials Sent To Wonderlabs (click here)
Supplement Facts
Serving Size 1 Capsule
Amount Per Serving
EDTA
(as Ethylenediaminetetraacetic Acid) 625 mg *
*Daily Value not established
Other ingredients: Gelatin, vegetable cellulose, vegetable magnesium sterate, silica.
Soy Free
DIRECTIONS: As a dietary supplement, take one (1) capsule two times daily preferably with a meal, (It can be taken before, during or after a meal).
CAUTION: If you are pregnant or nursing, consult your physician before taking this product.
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
Manufactured in an FDA Registered Facility using Good Manufacturing Practices (GMPs)
--------------------------------------------------------------------------------
Why Are Wonderlabs' Prices So Low Compared To Other Companies?
Over 40 years in the nutritional business. We manufacture in our own state-of-the-art FDA Registered Facility using Good Manufacturing Practices (GMPs) assuring correct potencies, freshness, quality and purity. We manufacture, package and ship from the same facility. We do no national advertising or multi-level marketing. From Wonderlabs to you for the lowest cost supplements on the net!
Click Here to see WONDERLABS' HEAVY METAL TESTING KIT.
Test your drinking water, saliva, urine, dust, paint and food.
All Available Sizes of this Item
Size Item No. Retail Discount Your Price
120 Capsules 9761 17.49 60% 6.99
250 Capsules 9762 32.99 60% 13.19
--------------------------------------------------------------------------------
Customers who purchased this item also purchased:
Co-Enzyme Q10
30 MG
Q10 ULTRA
Q10 30 mg. Energy for the Cells.
Your Price: $10.79
More Info
SUBLINGUAL B12
Vitamin B-12,
B6, Folic Acid and Biotin
Vegetarian Formula
Natural Cherry Flavored, 250 Sublingual Tablets
Your Price: $18.50
More Info
Category: Heart Health
--------------------------------------------------------------------------------
Click For More Information
--------------------------------------------------------------------------------
Top Categories
Allergy & Hayfever Antihistamine Anxiety Stress Tension Bone Support EDTA Chelation
Children's Products Diabetic Aids Fish Oil Omega 3's Glucosamine/Chondroitin/MSM
Leg Cramps Liver Health Men's Products Multi-Vitamins
Muscle Cramps, Tension & Stress Skin Care Sports Nutrition Vitamin-B
Vitamin-C Vitamin-E Weight Management Women's Products
--------------------------------------------------------------------------------
View All Categories
--------------------------------------------------------------------------------
Home | Company | Shipping | Customer Service | How To Shop | Contact Wonderlabs
®1996 - 2006 Wonder Laboratories. All rights reserved. 1.800.992.1672
Contact: Contact Wonderlabs
lama lee attacks
[18:06] Thursday September 6, 2007
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Date: Wed, 5 Sep 2007 14:40:49 -0400 (EDT)
From: Lee Denis
To: John Hutchison
Subject: Fwd: BEDBUGS!
Show headers:All | Normal
Reply | Reply to all | Forward | Forward as attachment | Delete View email as: Raw | XML
Lee Denis wrote:
Date: Tue, 4 Sep 2007 20:26:37 -0400 (EDT)
From: Lee Denis
Subject: BEDBUGS!
To: Dave Brown
Hello Dave,
It's Lee Denis here. I made a sucessful transition to BC Housing at Hall Towers, but nobody told me that these places are not just for seniors anymore, and they are mainly taking in Level 2 Disability people now. But these people do not have the supports that you provide at Lookout...its not a good thing. I pity the elderly. Maybe when I'm 60 I'll get safer and go private if the place turns into a 'Welfare Hotel'...too scary to contemplate!
I got so depressed today I almost felt like asking if I could return to Cliff Block! But no, it's early days yet and I'm just depressed because I developed a bedbug problem.
I have no idea how I got them...does anyone? But it was only about a month ago, so nobody will blame Cliff Block at least.....
They travel along the heating system, which is the old apartment kind that goes from room to room on the floor.
They use the same Pesticide people that Cliff Block uses, only they come EVERY THURSDAY! Don't forget Dave, there are two towers and over 200 residents, so I would say it is reasonable. Unfortunately, they were totally successful in eradicating the cockroaches that used to be in the two towers, and cockroaches are the only local enemy for a bedbug. Cockroaches will eat the eggs that they lay in the cracks in the tiles.
So, here we go....first I wanted to see if the fact that a dead bedbug gives birth...so I put a live one in a glass, then poured salt on the thing to see if that would kill it, but no - it crawled around on the salt. It did die eventually, as I had injured it in the capture. After a week or so a black sqiqqle lay beside the dead bedbug.
I had thought all the black sqiqqles I had been cleaning up in the cracks in my tile floor were dead fruitflies! Silly me.
The black sqiqqles are actually the larvae, or whatever the proper name is for such a thing. They have a sort of intelligence, as I have watched them climb my wall, UP of coarse, to try and get to wood table. They love wood, more on that later.
So, cleaning the cracks in the flooring of anything like a black sqiqqle is a good idea.
A few days later I looked in the glass and the sqiqqle was GONE..but I could vaguely make out the outline of a bedbug...the babies are translucent! Invisible to us. And they can move fast!
So, that is one experiment I tried.
The second experiment was to put a live one in the glass with 2 dead ones to see what would happen. After one day it has burrowed it's way into the dead one's belly to get at the blood!
Now I will tell you what a very bad infestation feels like...lonely. How can I visit anyone? I cannot see my 85 year old mother now, she is so very scared of getting a bedbug infestation, she knows that she could not stand the work.
The work - yes 8 or 9 loads of wash...plus purging all belongings that may be infested. I've done the wash thing 3 times now. Now I live with everything in plastic bags...it's all washed. I had to undo my new home and make it into an armed camp! It's so hard for me to move the furniture out from the wall each time so I just leave it out from the wall for the next fumigation!
Plus there is the cat...I cannot just leave for 6 hours. Blue kindly took me in to your lobby the first time (I wore clean clothes and took every precaution not to infest you)...but this time I must go to the 19th floor lobby with the cat...there is nothing there but an empty room and a wonderful view! But I cannot keep bothering Lookout. The manager at Hall Towers, Steve, is a wonderful man and is very helpful...in his way. He looks after BOTH BUILDINGS, so everything he does is 'on the run'...a very busy and hard-working man.
So, we have black sqiggles that seem to have the intelligence to climb a wall to get to my wood table. Here comes the clincher, THEY LIVE IN WOOD. My son, Shawn, lives in the West End of Vancouver where there is a bad infestation everywhere and they all are buying wrought iron and glass tables...and iron beds...
You must check all your wood furniture Dave, or get the pesticide people to check it. Some of those tables are bad looking. Also, it says on the sheet of paper they leave that nobody can bring in used furniture unless they check it first. I believe we should follow the instructions on that sheet of paper to the letter.
I did find out that heat to 117 degrees Farenheight will kill ALL STAGES of the bedbug...I am still dubious about the freezing.....
I read a book on pests and apparently in the 1930's there was a worldwide infestation of bedbugs and England suffered badly. Sweden put people up in tent cities in the parks while they fumigated they buildings and they were seriously thinking of building hotels for the people to stay in thru the winter fumigations.
Denmark came up with a good idea, they painted the walls in an oily substance almost to the ceiling (bedbugs cannot climb a smooth surface) and the made some sort of concave molding for the walls.
Another thing I read, I can copy this if you like - you can be in an iron bed all safe and sound, and they bedbugs will climb the wall and the ceiling and DROP onto you - their food.
These bugs are prehistoric, they live to eat and breed.
Everyone says I'm too 'into' this thing and I should take my mind off of it. But I cannot really have company in my infested apartment and feel good about it and I cannot really visit people for the same reason. I feel like I'm in some sort of isolation! Quaranteen if you will. I am lucky that my girlfriend, Corinne, is brave enough to visit me! It's very depressing. It's also a lot of work, a LOT of work...the laundry MUST be done!
I have no idea if they will be gone after my 3 fumigations. I am expecting the second fumigation on Thursday...they use very strong poison....I was in the room a hot 3 minutes before my bowells exploded when I returned home after fumigation number one. I put my bare arm on the table and my arm burned because there was a wet spot of spray!
My first thought was that the SECOND fumigation was the IMPORTANT one, as all the big ones would have died, and they the second wave of poison would kill all of the hundreds of hatching egg things. Think Dave, if you see 3 big bedbugs and a female lays 300 eggs in 3 hours...in all the cracks in the floors and in the wood - they the HATCHING EGGS must be the important spray.
BUT I caught 2 big guys just today...I just pick them up now I'm so used to them...and I have no idea where the big ones came from!
I don't think anyone has the answer, unless we bring back pet cockroaches! They are like aliens and they are truly creepy bugs...then again, I guess if we look at any life cycle of a bug, yes, it's creepy...
I hope this information helps you...I'm at the library, so I'll try and get that book on the 1930 infestation and copy the pages, it's a good read.
I really need a mattress for Thursday or Friday Dave...my Mom will buy me a metal daybed and I will cover the mattress with plastic, but she cannot affort to get it for my until after the 3rd spray. My foamy is so infested that it must be thrown away!
I'm 57 years old and starting to feel the effects of sleeping on the floor, up and down, up and down...God.
OK Dave, any questions, just ask!
or email me at:
Thanks for listening,
Lee Denis
Lee Denis
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Date: Wed, 5 Sep 2007 14:40:49 -0400 (EDT)
From: Lee Denis
To: John Hutchison
Subject: Fwd: BEDBUGS!
Show headers:All | Normal
Reply | Reply to all | Forward | Forward as attachment | Delete View email as: Raw | XML
Lee Denis
Date: Tue, 4 Sep 2007 20:26:37 -0400 (EDT)
From: Lee Denis
Subject: BEDBUGS!
To: Dave Brown
Hello Dave,
It's Lee Denis here. I made a sucessful transition to BC Housing at Hall Towers, but nobody told me that these places are not just for seniors anymore, and they are mainly taking in Level 2 Disability people now. But these people do not have the supports that you provide at Lookout...its not a good thing. I pity the elderly. Maybe when I'm 60 I'll get safer and go private if the place turns into a 'Welfare Hotel'...too scary to contemplate!
I got so depressed today I almost felt like asking if I could return to Cliff Block! But no, it's early days yet and I'm just depressed because I developed a bedbug problem.
I have no idea how I got them...does anyone? But it was only about a month ago, so nobody will blame Cliff Block at least.....
They travel along the heating system, which is the old apartment kind that goes from room to room on the floor.
They use the same Pesticide people that Cliff Block uses, only they come EVERY THURSDAY! Don't forget Dave, there are two towers and over 200 residents, so I would say it is reasonable. Unfortunately, they were totally successful in eradicating the cockroaches that used to be in the two towers, and cockroaches are the only local enemy for a bedbug. Cockroaches will eat the eggs that they lay in the cracks in the tiles.
So, here we go....first I wanted to see if the fact that a dead bedbug gives birth...so I put a live one in a glass, then poured salt on the thing to see if that would kill it, but no - it crawled around on the salt. It did die eventually, as I had injured it in the capture. After a week or so a black sqiqqle lay beside the dead bedbug.
I had thought all the black sqiqqles I had been cleaning up in the cracks in my tile floor were dead fruitflies! Silly me.
The black sqiqqles are actually the larvae, or whatever the proper name is for such a thing. They have a sort of intelligence, as I have watched them climb my wall, UP of coarse, to try and get to wood table. They love wood, more on that later.
So, cleaning the cracks in the flooring of anything like a black sqiqqle is a good idea.
A few days later I looked in the glass and the sqiqqle was GONE..but I could vaguely make out the outline of a bedbug...the babies are translucent! Invisible to us. And they can move fast!
So, that is one experiment I tried.
The second experiment was to put a live one in the glass with 2 dead ones to see what would happen. After one day it has burrowed it's way into the dead one's belly to get at the blood!
Now I will tell you what a very bad infestation feels like...lonely. How can I visit anyone? I cannot see my 85 year old mother now, she is so very scared of getting a bedbug infestation, she knows that she could not stand the work.
The work - yes 8 or 9 loads of wash...plus purging all belongings that may be infested. I've done the wash thing 3 times now. Now I live with everything in plastic bags...it's all washed. I had to undo my new home and make it into an armed camp! It's so hard for me to move the furniture out from the wall each time so I just leave it out from the wall for the next fumigation!
Plus there is the cat...I cannot just leave for 6 hours. Blue kindly took me in to your lobby the first time (I wore clean clothes and took every precaution not to infest you)...but this time I must go to the 19th floor lobby with the cat...there is nothing there but an empty room and a wonderful view! But I cannot keep bothering Lookout. The manager at Hall Towers, Steve, is a wonderful man and is very helpful...in his way. He looks after BOTH BUILDINGS, so everything he does is 'on the run'...a very busy and hard-working man.
So, we have black sqiggles that seem to have the intelligence to climb a wall to get to my wood table. Here comes the clincher, THEY LIVE IN WOOD. My son, Shawn, lives in the West End of Vancouver where there is a bad infestation everywhere and they all are buying wrought iron and glass tables...and iron beds...
You must check all your wood furniture Dave, or get the pesticide people to check it. Some of those tables are bad looking. Also, it says on the sheet of paper they leave that nobody can bring in used furniture unless they check it first. I believe we should follow the instructions on that sheet of paper to the letter.
I did find out that heat to 117 degrees Farenheight will kill ALL STAGES of the bedbug...I am still dubious about the freezing.....
I read a book on pests and apparently in the 1930's there was a worldwide infestation of bedbugs and England suffered badly. Sweden put people up in tent cities in the parks while they fumigated they buildings and they were seriously thinking of building hotels for the people to stay in thru the winter fumigations.
Denmark came up with a good idea, they painted the walls in an oily substance almost to the ceiling (bedbugs cannot climb a smooth surface) and the made some sort of concave molding for the walls.
Another thing I read, I can copy this if you like - you can be in an iron bed all safe and sound, and they bedbugs will climb the wall and the ceiling and DROP onto you - their food.
These bugs are prehistoric, they live to eat and breed.
Everyone says I'm too 'into' this thing and I should take my mind off of it. But I cannot really have company in my infested apartment and feel good about it and I cannot really visit people for the same reason. I feel like I'm in some sort of isolation! Quaranteen if you will. I am lucky that my girlfriend, Corinne, is brave enough to visit me! It's very depressing. It's also a lot of work, a LOT of work...the laundry MUST be done!
I have no idea if they will be gone after my 3 fumigations. I am expecting the second fumigation on Thursday...they use very strong poison....I was in the room a hot 3 minutes before my bowells exploded when I returned home after fumigation number one. I put my bare arm on the table and my arm burned because there was a wet spot of spray!
My first thought was that the SECOND fumigation was the IMPORTANT one, as all the big ones would have died, and they the second wave of poison would kill all of the hundreds of hatching egg things. Think Dave, if you see 3 big bedbugs and a female lays 300 eggs in 3 hours...in all the cracks in the floors and in the wood - they the HATCHING EGGS must be the important spray.
BUT I caught 2 big guys just today...I just pick them up now I'm so used to them...and I have no idea where the big ones came from!
I don't think anyone has the answer, unless we bring back pet cockroaches! They are like aliens and they are truly creepy bugs...then again, I guess if we look at any life cycle of a bug, yes, it's creepy...
I hope this information helps you...I'm at the library, so I'll try and get that book on the 1930 infestation and copy the pages, it's a good read.
I really need a mattress for Thursday or Friday Dave...my Mom will buy me a metal daybed and I will cover the mattress with plastic, but she cannot affort to get it for my until after the 3rd spray. My foamy is so infested that it must be thrown away!
I'm 57 years old and starting to feel the effects of sleeping on the floor, up and down, up and down...God.
OK Dave, any questions, just ask!
or email me at:
Thanks for listening,
Lee Denis
Lee Denis
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Be smarter than spam. See how smart SpamGuard is at giving junk email the boot with the All-new Yahoo! Mail
Lee Denis
e-mail -
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Be smarter than spam. See how smart SpamGuard is at giving junk email the boot with the All-new Yahoo! Mail
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